CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007813
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Merlin 
Protein Synonyms/Alias
 Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomin 
Gene Name
 Nf2 
Gene Synonyms/Alias
 Nf-2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
364ERRLLQMKEEATMANubiquitination[1]
396QITEEEAKLLAQKAAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex (By similarity). Plays a role in lens development and is required for complete fiber cell terminal differentiation, maintenance of cell polarity and separation of the lens vesicle from the corneal epithelium. 
Sequence Annotation
 DOMAIN 22 311 FERM.
 MOD_RES 518 518 Phosphoserine; by PAK (By similarity).  
Keyword
 3D-structure; Alternative splicing; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Nucleus; Phosphoprotein; Reference proteome; Tumor suppressor; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 596 AA 
Protein Sequence
MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCEMK WKGKDLFDLV CRTLGLRETW 60
FFGLQYTIKD TVAWLKMDKK VLDHDVSKEE PVTFHFLAKF YPENAEEELV QEITQHLFFL 120
QVKKQILDEK VYCPPEASVL LASYAVQAKY GDYDPSVHKR GFLAQEELLP KRVINLYQMT 180
PEMWEERITA WYAEHRGRAR DEAEMEYLKI AQDLEMYGVN YFTIRNKKGT ELLLGVDALG 240
LHIYDPENRL TPKISFPWNE IRNISYSDKE FTIKPLDKKI DVFKFNSSKL RVNKLILQLC 300
IGNHDLFMRR RKADSLEVQQ MKAQAREEKA RKQMERQRLA REKQMREEAE RTRDELERRL 360
LQMKEEATMA NEALMRSEET ADLLAEKAQI TEEEAKLLAQ KAAEAEQEMQ RIKATAIRTE 420
EEKRLMEQKV LEAEVLALKM AEESERRAKE ADQLKQDLQE AREAERRAKQ KLLEIATKPT 480
YPPMNPIPPP LPPDIPSFDI IADSLSFDFK DTDMKRLSME IEKEKVEYME KSKHLQEQLN 540
ELKTEIEALK LKERETALDV LHSESSDRGG PSSKHNTIKK LTLQSAKSRV AFFEEL 596 
Gene Ontology
 GO:0005912; C:adherens junction; IMP:MGI.
 GO:0032154; C:cleavage furrow; IDA:MGI.
 GO:0030864; C:cortical actin cytoskeleton; IDA:MGI.
 GO:0005769; C:early endosome; IEA:Compara.
 GO:0019898; C:extrinsic to membrane; IEA:InterPro.
 GO:0030175; C:filopodium; IDA:MGI.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0001726; C:ruffle; IDA:MGI.
 GO:0030036; P:actin cytoskeleton organization; IEA:Compara.
 GO:0045216; P:cell-cell junction organization; IMP:MGI.
 GO:0007398; P:ectoderm development; IMP:MGI.
 GO:0070306; P:lens fiber cell differentiation; IMP:UniProtKB.
 GO:0001707; P:mesoderm formation; IMP:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
 GO:0022408; P:negative regulation of cell-cell adhesion; IEA:Compara.
 GO:0008156; P:negative regulation of DNA replication; IEA:Compara.
 GO:0043409; P:negative regulation of MAPK cascade; IMP:MGI.
 GO:0006469; P:negative regulation of protein kinase activity; IDA:MGI.
 GO:0042518; P:negative regulation of tyrosine phosphorylation of Stat3 protein; IEA:Compara.
 GO:0042524; P:negative regulation of tyrosine phosphorylation of Stat5 protein; IEA:Compara.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:MGI.
 GO:0051496; P:positive regulation of stress fiber assembly; IEA:Compara.
 GO:0035330; P:regulation of hippo signaling cascade; IEA:Compara.
 GO:0014010; P:Schwann cell proliferation; IEA:Compara. 
Interpro
 IPR019749; Band_41_domain.
 IPR019750; Band_41_fam.
 IPR011174; ERM.
 IPR011259; ERM_C_dom.
 IPR000798; Ez/rad/moesin_like.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR019747; FERM_CS.
 IPR000299; FERM_domain.
 IPR018979; FERM_N.
 IPR018980; FERM_PH-like_C.
 IPR008954; Moesin.
 IPR011993; PH_like_dom. 
Pfam
 PF00769; ERM
 PF09380; FERM_C
 PF00373; FERM_M
 PF09379; FERM_N 
SMART
 SM00295; B41 
PROSITE
 PS00660; FERM_1
 PS00661; FERM_2
 PS50057; FERM_3 
PRINTS
 PR00935; BAND41.
 PR00661; ERMFAMILY.