UniProt Accession

 SLAP1_HUMAN; Q13239; Q9UMQ8 

Genbank Protein ID

 U30473; D89077; U44403; BC007042; AJ238591 

Genbank Nucleotide ID

 AAC50357.1; BAA13758.1; AAC27662.1; AAH07042.1; CAB53536.1 

Protein Name

 Src-like-adapter 

Protein Synonyms/Alias

 Src-like-adapter protein 1; SLAP-1; hSLAP 

Gene Name

 SLA 

Gene Synonyms/Alias

 SLAP; SLAP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
60	SDEGGWWKAISLSTG	ubiquitination	[1]
93	FEGLGRDKAEELLQL	ubiquitination	[1]
104	LLQLPDTKVGSFMIR	ubiquitination	[1]
117	IRESETKKGFYSLSV	ubiquitination	[1]
197	SPVTLRQKTVDWRRV	ubiquitination	[1]
252	TSFDRKKKSISLMYG	ubiquitination	[1]
262	SLMYGGSKRKSSFFS	ubiquitination	[1]
264	MYGGSKRKSSFFSSP	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. 

Sequence Annotation

 DOMAIN 22 82 SH3.
 DOMAIN 84 175 SH2.
 REGION 212 276 SLA C-terminal.
 MOD_RES 273 273 Phosphotyrosine (By similarity).
 LIPID 2 2 N-myristoyl glycine (By similarity).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Endosome; Lipoprotein; Myristate; Phosphoprotein; Polymorphism; Reference proteome; SH2 domain; SH3 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 276 AA 

Protein Sequence

Gene Ontology

 GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
 GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc. 

Interpro

 IPR000980; SH2.
 IPR001452; SH3_domain. 

Pfam

 PF00017; SH2
 PF00018; SH3_1 

SMART

 SM00252; SH2
 SM00326; SH3 

PROSITE

 PS50001; SH2
 PS50002; SH3 

PRINTS

 PR00401; SH2DOMAIN.