CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011325
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GTP cyclohydrolase 1 
Protein Synonyms/Alias
 GTP cyclohydrolase I; GTP-CH-I 
Gene Name
 Gch1 
Gene Synonyms/Alias
 Gch 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
36KSRPPEAKGAQPADAubiquitination[1]
45AQPADAWKAGRHRSEubiquitination[1]
84PQRQGLLKTPWRAATubiquitination[1]
151HIGYLPNKQVLGLSKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence (By similarity). 
Sequence Annotation
 METAL 132 132 Zinc (By similarity).
 METAL 135 135 Zinc (By similarity).
 METAL 203 203 Zinc (By similarity).
 MOD_RES 51 51 Phosphoserine (By similarity).
 MOD_RES 72 72 Phosphoserine (By similarity).  
Keyword
 Allosteric enzyme; Complete proteome; Cytoplasm; GTP-binding; Hydrolase; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Tetrahydrobiopterin biosynthesis; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 241 AA 
Protein Sequence
MEKPRGVRCT NGFSERELPR PGASPPAEKS RPPEAKGAQP ADAWKAGRHR SEEENQVNLP 60
KLAAAYSSIL LSLGEDPQRQ GLLKTPWRAA TAMQYFTKGY QETISDVLND AIFDEDHDEM 120
VIVKDIDMFS MCEHHLVPFV GRVHIGYLPN KQVLGLSKLA RIVEIYSRRL QVQERLTKQI 180
AVAITEALQP AGVGVVIEAT HMCMVMRGVQ KMNSKTVTST MLGVFREDPK TREEFLTLIR 240
S 241 
Gene Ontology
 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0031965; C:nuclear membrane; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:Compara.
 GO:0050662; F:coenzyme binding; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003934; F:GTP cyclohydrolase I activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:Compara.
 GO:0035998; P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0042416; P:dopamine biosynthetic process; IEA:Compara.
 GO:0006184; P:GTP catabolic process; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0045776; P:negative regulation of blood pressure; IEA:Compara.
 GO:0050884; P:neuromuscular process controlling posture; IEA:Compara.
 GO:0051000; P:positive regulation of nitric-oxide synthase activity; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:Compara.
 GO:0014916; P:regulation of lung blood pressure; IMP:MGI.
 GO:0034341; P:response to interferon-gamma; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0048265; P:response to pain; ISS:UniProtKB.
 GO:0034612; P:response to tumor necrosis factor; IEA:Compara.
 GO:0006729; P:tetrahydrobiopterin biosynthetic process; IC:MGI.
 GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro.
 GO:0042311; P:vasodilation; IEA:Compara. 
Interpro
 IPR001474; GTP_CycHdrlase_I.
 IPR020602; GTP_CycHdrlase_I/CN_OxRdtase.
 IPR018234; GTP_CycHdrlase_I_CS. 
Pfam
 PF01227; GTP_cyclohydroI 
SMART
  
PROSITE
 PS00859; GTP_CYCLOHYDROL_1_1
 PS00860; GTP_CYCLOHYDROL_1_2 
PRINTS