CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010953
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein TBF1 
Protein Synonyms/Alias
 TBF-alpha; TTAGGG repeat-binding factor 1 
Gene Name
 TBF1 
Gene Synonyms/Alias
 YPL128C; LPI16C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
443DLYGPGGKITENLKNubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of gene expression. 52 binding sites have been identified, distributed over 15 chromosomes. A member of the general regulatory factors (GRFs) which act as genome partitioners. Acts as a chromatin insulator which are known as STARs (Subtelomeric anti-silencing region). STARs prevent negative or positive transcription influence by extending across chromotin to a promoter. 
Sequence Annotation
 DOMAIN 404 460 HTH myb-type.
 DNA_BIND 431 456 H-T-H motif (By similarity).  
Keyword
 Cell cycle; Chromosome; Complete proteome; DNA-binding; Nucleus; Reference proteome; Telomere; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 562 AA 
Protein Sequence
MDSQVPNNNE SLNRFNDIIQ SLPARTRLTI CSLCLLDNIS TQLLRFLILN ANSPNIIAVL 60
TDQTAFLSSG ETEIFQTLVK LFKQIRMIYH TRSPLLSVHD VAPGLWFPNS PPPLILRGHE 120
AFIITAIRKA NLLTFLLTSL NCLNYGFELL QSIFLDIFCP NTNTVGNNSL EQSGKFLKSQ 180
AILYLDLKTQ AYIAGLKEFQ DETNEISLEK KQELLDLIFP SNLADILVQR RTGDSGDITL 240
LTPSEKDFVE RCDRRRENLK IVQDFNSLTQ SYEWAQFIRE LLDYCNKNMG LIIWGRKGRG 300
KSPLYDFDVN EFDPQVLFST GTRTVEFMDD QNQPSSASAF LSTARPNHYS THTPTTDVSS 360
KNPAITQSIV DAAVAASMSN SSSGPHSSHN NSSNSNNNGS IGLRKPKAKR TWSKEEEEAL 420
VEGLKEVGPS WSKILDLYGP GGKITENLKN RTQVQLKDKA RNWKLQYLKS GKPLPDYLIK 480
VTGNLEKIYK AKKKFSQSPN SSTIMEQNLS QHPSSAASAT EDTQTHQEDS HGQNSDNMPS 540
NGLFGNSTSD NTGFDPHLED GM 562 
Gene Ontology
 GO:0000784; C:nuclear chromosome, telomeric region; IDA:SGD.
 GO:0043035; F:chromatin insulator sequence binding; IDA:SGD.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:SGD.
 GO:0000982; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity; IDA:SGD.
 GO:0042162; F:telomeric DNA binding; IDA:SGD.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0031936; P:negative regulation of chromatin silencing; IDA:SGD.
 GO:0032211; P:negative regulation of telomere maintenance via telomerase; IGI:SGD.
 GO:0001015; P:snoRNA transcription from an RNA polymerase II promoter; IMP:SGD.
 GO:0010833; P:telomere maintenance via telomere lengthening; IDA:SGD. 
Interpro
 IPR009057; Homeodomain-like.
 IPR017930; Myb_dom.
 IPR001005; SANT/Myb.
 IPR013867; Telomere_rpt-bd_fac_dimer_dom. 
Pfam
 PF00249; Myb_DNA-binding
 PF08558; TRF 
SMART
 SM00717; SANT 
PROSITE
 PS51294; HTH_MYB 
PRINTS