CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032352
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Adenylate cyclase type 3 
Protein Synonyms/Alias
  
Gene Name
 Adcy3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
293HVADEMLKDMKKDESubiquitination[1]
428LGGVLGQKRWQYDVWubiquitination[1]
1046MLRIGMNKGGVLAGVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Lyase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1144 AA 
Protein Sequence
MPRNQGFSDP EYSAEYSAEY SVSLPSDPDR GVGRTHEISV RNSGSCLCLP RFMRLTFVPE 60
SLENLYQTYF KRQRHETLLV LVVFAALFDC YVVVMCAVVF SSDKLAPLMV AGFGLVLDII 120
LFVLCKKGLL PDRVSRKVVP YLLWLLISAQ IFSYLGLNFS RAHAASDTVG WQAFFVFSFF 180
ITLPLSLSPI VIISVVSCVV HTLVLGVTVA QQQQDELEGM QLLREILANV FLYLCAIIVG 240
IMSYYMADRK HRKAFLEARQ SLEVKMNLEE QSQQQENLML SILPKHVADE MLKDMKKDES 300
QKDQQQFNTM YMYRHENVSI LFADIVGFTQ LSSACSAQEL VKLLNELFAR FDKLAAKYHQ 360
LRIKILGDCY YCICGLPDYR EDHAVCSILM GLAMVEAISY VREKTKTGVD MRVGVHTGTV 420
LGGVLGQKRW QYDVWSTDVT VANKMEAGGI PGRVHISQST MDCLKGEFDV EPGDGGSRCD 480
YLDEKGIETY LIIASKPEVK KTAQNGLNGS AVPNGAPASS KPSSPALIET KEPNGSAHAS 540
GSTSEEAEEQ EAQADNPSFP NPRRRLRLQD LADRVVDASE DEHELNQLLN EALLERESAQ 600
VVKKRNTFLL TMRFMDPEME TRYSVEKEKQ SGAAFSCSCV VLFCTAMVEI LIDPWLMTNY 660
VTFVVGEVLL LILTICSMAA IFPRSFPKKL VAFSSWIDRT RWARNTWAML AIFILVMANV 720
VDMLSCLQYY MGPYNMTAGM ELDGGCMENP KYYNYVAVLS LIATIMLVQV SHMVKLTLML 780
LVTGAVTALN LYAWCPVFDE YDHKRFQEKD SPMVALEKMQ VLATPGLNGT DRLPLVPSKY 840
SMTVMMFVMM LSFYYFSRHV EKLARTLFLW KIEVHDQKER VYEMRRWNEA LVTNMLPEHV 900
ARHFLGSKKR DEELYSQSYD EIGVMFASLP NFADFYTEES INNGGIECLR FLNEIISDFD 960
SLLDNPKFRV ITKIKTIGST YMAASGVTPD VNTNGFTSSS KEEKSDKERW QHLADLADFA 1020
LAMKDTLTNI NNQSFNNFML RIGMNKGGVL AGVIGARKPH YDIWGNTVNV ASRMESTGVM 1080
GNIQVVEETQ VILREYGFRF VRRGPIFVKG KGELLTFFLK GRDRPAAFPN GSSVTLPHQV 1140
VDNP 1144 
Gene Ontology
 GO:0005929; C:cilium; IDA:MGI.
 GO:0005886; C:plasma membrane; TAS:MGI.
 GO:0004016; F:adenylate cyclase activity; TAS:MGI.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0007190; P:activation of adenylate cyclase activity; TAS:MGI.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro. 
Interpro
 IPR001054; A/G_cyclase.
 IPR018297; A/G_cyclase_CS. 
Pfam
 PF00211; Guanylate_cyc 
SMART
 SM00044; CYCc 
PROSITE
 PS00452; GUANYLATE_CYCLASE_1
 PS50125; GUANYLATE_CYCLASE_2 
PRINTS