CPLM-015967

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-015967

UniProt Accession

UBE3D_HUMAN; Q7Z6J8; B4DP63; Q5T4W2; Q6IPR4; Q75UG0; Q9NT42

Genbank Protein ID

AB126062; AK298205; AL034377; AL139333; AL357121; AL355613; AL139333; AL034377; AL357121; AL355613; AL357121; AL034377; AL139333; AL355613; CH471051; BC053645; BC071763; BC101512; BC101538; AL137544

Genbank Nucleotide ID

BAD01604.1; BAG60475.1; CAM28304.1; CAM28304.1; CAM28304.1; CAM28304.1; CAI15282.2; CAI15282.2; CAI15282.2; CAI15282.2; CAI13740.2; CAI13740.2; CAI13740.2; CAI13740.2; EAW48681.1; AAH53645.1; AAH71763.1; AAI01513.1; AAI01539.1; CAB70802.1

Protein Name

E3 ubiquitin-protein ligase E3D

Protein Synonyms/Alias

UbcH10-binding protein with a HECT-like domain; Ubiquitin-conjugating enzyme E2C-binding protein

Gene Name

UBE3D

Gene Synonyms/Alias

C6orf157; H10BH; UBE2CBP

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
88	LRLQTQAKLGTKLIS	ubiquitination	[1]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.

Sequence Annotation

REGION 235 257 Interaction with UBE2C.
REGION 353 389 HECT-like.

Keyword

Complete proteome; Cytoplasm; Ligase; Polymorphism; Reference proteome; Ubl conjugation; Ubl conjugation pathway.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

389 AA

Protein Sequence

MAASAAETRV FLEVRGQLQS ALLILGEPKE GGMPMNISIM PSSLQMKTPE GCTEIQLPAE 60
VRLVPSSCRG LQFVVGDGLH LRLQTQAKLG TKLISMFNQS SQTQECCTFY CQSCGEVIIK 120
DRKLLRVLPL PSENWGALVG EWCCHPDPFA NKSLHPQEND CFIGDSFFLV NLRTSLWQQR 180
PELSPVEMCC VSSDNHCKLE PKANTKVICK RCKVMLGETV SSETTKFYMT EIIIQSSERS 240
FPIIPRSWFV QSVIAQCLVQ LSSARSTFRF TIQGQDDKVY ILLWLLNSDS LVIESLRNSK 300
YIKKFPLLEN TFKADSSSAW SAVKVLYQPC IKSRNEKLVS LWESDISVHP LTLPSATCLE 360
LLLILSKSNA NLPSSLRRVN SFQVAFLKM 389

Gene Ontology

GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.

Interpro

IPR019193; UBQ-conj_enz_E2-bd_prot.

Pfam

PF09814; DUF2351

SMART

PROSITE

PRINTS