CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018641
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 V-type proton ATPase 116 kDa subunit a isoform 4 
Protein Synonyms/Alias
 V-ATPase 116 kDa isoform a4; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4; Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform 
Gene Name
 Atp6v0a4 
Gene Synonyms/Alias
 Atp6n1b 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
83ILIQVPEKDAETPLPubiquitination[1]
118NQSHQALKKSFLELTubiquitination[1]
128FLELTELKYLLKKTQubiquitination[1]
169IPAFMTGKLGFTAGVubiquitination[1]
214LLEDPVTKEEIKKNIubiquitination[1]
337ADTRHIKKALEQGMEubiquitination[1]
360IMTEVETKTDPPTFNubiquitination[1]
371PTFNRTNKFTAGFQNubiquitination[1]
691DHSGHSSKKTAGAHGubiquitination[1]
817FYEGAGSKFSPFSFKubiquitination[1]
824KFSPFSFKHVLEGTAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney (By similarity). 
Sequence Annotation
  
Keyword
 Cell membrane; Complete proteome; Hydrogen ion transport; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 833 AA 
Protein Sequence
MASVFRSEEM CLSQVFLQVE AAYCCVAELG ELGLVQFKDL NANVNSFQRK FVNEVRRCES 60
LERILRFLED EMQNEILIQV PEKDAETPLP REMITLETTL EKLEGELQEA NQSHQALKKS 120
FLELTELKYL LKKTQDFFET ETNLGEDFFV EDTSGLLELR TIPAFMTGKL GFTAGVINRE 180
RMASFERLLW RVCRGNVYLK FSEMDTLLED PVTKEEIKKN IFIIFYQGEQ LRLKIKKICD 240
GFRATIYPCP EHAAERREML TSVNVRLEDL ITVITQTESH RQRLLQEAAA NWHSWVIKVQ 300
KMKAVYHVLN MCNIDVTQQC IIAEIWFPVA DTRHIKKALE QGMELSGSSM IPIMTEVETK 360
TDPPTFNRTN KFTAGFQNIV DAYGVGSYRE INPAPYTIIT FPFLFAVMFG DCGHGMVMLM 420
AALWMVLNER HLLAQKSTNE MWNIFFNGRY LILLMGIFSI YTGLIYNDCF SKSFNIFGSS 480
WSVQPMFRNG TWNTHIVENS PYLQLDPAIP GVYSGNPYPF GIDPIWNLAS NKLTFLNSYK 540
MKMSVILGIA HMIFGVILSL FNHIYFRRTL NIILQFIPEM IFMLSLFGYL VFMIIFKWCR 600
YDAHTSRKAP SILIHFIGMF LFDYDDSSNA PLYGHQQEVQ TFFVIIALVS VPWMLLIKPF 660
VLRAKHQKSQ LQSFTIHEDA VEGDHSGHSS KKTAGAHGMK DGHEEEFNFG DIFVHQAIHT 720
IEYCLGCISN TASYLRLWAL SLAHAELSEV LWTMVMSIGL RLQGWAGLVG VFIIFAVFAV 780
LTVAILLVME GLSAFLHALR LHWVEFQNKF YEGAGSKFSP FSFKHVLEGT AEE 833 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
 GO:0005903; C:brush border; IDA:MGI.
 GO:0031526; C:brush border membrane; IEA:Compara.
 GO:0005768; C:endosome; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IPI:MGI.
 GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
 GO:0008553; F:hydrogen-exporting ATPase activity, phosphorylative mechanism; ISA:MGI.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IPI:MGI.
 GO:0007588; P:excretion; IEA:Compara.
 GO:0001503; P:ossification; IEA:Compara.
 GO:0006885; P:regulation of pH; IEA:Compara.
 GO:0007605; P:sensory perception of sound; IEA:Compara. 
Interpro
 IPR002490; V-ATPase_116kDa_su.
 IPR026028; V-type_ATPase_116kDa_su_euka. 
Pfam
 PF01496; V_ATPase_I 
SMART
  
PROSITE
  
PRINTS