CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010778
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Apolipoprotein A-I 
Protein Synonyms/Alias
 Apo-AI; ApoA-I; Apolipoprotein A1; Truncated apolipoprotein A-I 
Gene Name
 Apoa1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
35QSQWDKVKDFANVYVubiquitination[1]
46NVYVDAVKDSGRDYVubiquitination[1]
119DLEEVKQKVQPYLDEubiquitination[1]
130YLDEFQKKWKEDVELacetylation[2]
132DEFQKKWKEDVELYRacetylation[2]
141DVELYRQKVAPLGAEubiquitination[1]
156LQESARQKLQELQGRacetylation[3]
156LQESARQKLQELQGRubiquitination[1]
205AQRLAELKSNPTLNEubiquitination[1]
256QVQSVIDKASETLTAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 
Functional Description
 Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. 
Sequence Annotation
 REPEAT 67 88 1.
 REPEAT 89 110 2.
 REPEAT 111 121 3; half-length.
 REPEAT 122 143 4.
 REPEAT 144 165 5.
 REPEAT 166 187 6.
 REPEAT 188 207 7; truncated.
 REPEAT 208 229 8.
 REPEAT 230 240 9; half-length.
 REPEAT 241 264 10.
 REGION 67 264 10 X approximate tandem repeats.
 MOD_RES 109 109 Methionine sulfoxide (By similarity).  
Keyword
 3D-structure; Cholesterol metabolism; Complete proteome; HDL; Lipid metabolism; Lipid transport; Lipoprotein; Oxidation; Palmitate; Phosphoprotein; Reference proteome; Repeat; Secreted; Signal; Steroid metabolism; Sterol metabolism; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 264 AA 
Protein Sequence
MKAVVLAVAL VFLTGSQAWH VWQQDEPQSQ WDKVKDFANV YVDAVKDSGR DYVSQFESSS 60
LGQQLNLNLL ENWDTLGSTV SQLQERLGPL TRDFWDNLEK ETDWVRQEMN KDLEEVKQKV 120
QPYLDEFQKK WKEDVELYRQ KVAPLGAELQ ESARQKLQEL QGRLSPVAEE FRDRMRTHVD 180
SLRTQLAPHS EQMRESLAQR LAELKSNPTL NEYHTRAKTH LKTLGEKARP ALEDLRHSLM 240
PMLETLKTQV QSVIDKASET LTAQ 264 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0030139; C:endocytic vesicle; IEA:Compara.
 GO:0005615; C:extracellular space; IDA:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0034366; C:spherical high-density lipoprotein particle; IEA:Compara.
 GO:0034361; C:very-low-density lipoprotein particle; IEA:Compara.
 GO:0001540; F:beta-amyloid binding; IEA:Compara.
 GO:0015485; F:cholesterol binding; IEA:Compara.
 GO:0017127; F:cholesterol transporter activity; IDA:MGI.
 GO:0008035; F:high-density lipoprotein particle binding; IDA:MGI.
 GO:0055102; F:lipase inhibitor activity; IEA:Compara.
 GO:0008289; F:lipid binding; IDA:MGI.
 GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IEA:Compara.
 GO:0005543; F:phospholipid binding; IEA:Compara.
 GO:0005548; F:phospholipid transporter activity; IEA:Compara.
 GO:0030325; P:adrenal gland development; IMP:MGI.
 GO:0043534; P:blood vessel endothelial cell migration; IMP:MGI.
 GO:0006695; P:cholesterol biosynthetic process; IMP:MGI.
 GO:0033344; P:cholesterol efflux; IDA:MGI.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0070508; P:cholesterol import; IEA:Compara.
 GO:0001935; P:endothelial cell proliferation; IMP:MGI.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0008211; P:glucocorticoid metabolic process; IMP:MGI.
 GO:0034380; P:high-density lipoprotein particle assembly; IEA:Compara.
 GO:0019915; P:lipid storage; IMP:MGI.
 GO:0042158; P:lipoprotein biosynthetic process; IMP:MGI.
 GO:0060354; P:negative regulation of cell adhesion molecule production; IEA:Compara.
 GO:0002740; P:negative regulation of cytokine secretion involved in immune response; IEA:Compara.
 GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Compara.
 GO:0051346; P:negative regulation of hydrolase activity; IGI:MGI.
 GO:0050728; P:negative regulation of inflammatory response; IEA:Compara.
 GO:0050713; P:negative regulation of interleukin-1 beta secretion; IEA:Compara.
 GO:0060192; P:negative regulation of lipase activity; IEA:Compara.
 GO:0010804; P:negative regulation of tumor necrosis factor-mediated signaling pathway; IEA:Compara.
 GO:0010903; P:negative regulation of very-low-density lipoprotein particle remodeling; IEA:Compara.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0018206; P:peptidyl-methionine modification; ISS:UniProtKB.
 GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:Compara.
 GO:0033700; P:phospholipid efflux; IEA:Compara.
 GO:0055091; P:phospholipid homeostasis; IEA:Compara.
 GO:0006644; P:phospholipid metabolic process; IMP:MGI.
 GO:0010873; P:positive regulation of cholesterol esterification; IEA:Compara.
 GO:0051345; P:positive regulation of hydrolase activity; IEA:Compara.
 GO:0051347; P:positive regulation of transferase activity; IMP:MGI.
 GO:0018158; P:protein oxidation; ISS:UniProtKB.
 GO:0050821; P:protein stabilization; IEA:Compara.
 GO:0032489; P:regulation of Cdc42 protein signal transduction; IEA:Compara.
 GO:0030300; P:regulation of intestinal cholesterol absorption; IDA:MGI.
 GO:0001932; P:regulation of protein phosphorylation; IDA:MGI.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0043691; P:reverse cholesterol transport; IEA:Compara.
 GO:0070328; P:triglyceride homeostasis; IEA:Compara. 
Interpro
 IPR013326; ApoA.
 IPR000074; ApoA1_A4_E. 
Pfam
 PF01442; Apolipoprotein 
SMART
  
PROSITE
  
PRINTS