| Tag | Content |
|---|
| CPLM ID | CPLM-010638 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rho GTPase-activating protein 5 |
Protein Synonyms/Alias | Rho-type GTPase-activating protein 5; p190-B |
Gene Name | Arhgap5 |
Gene Synonyms/Alias | Rhogap5 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 278 | TATDKFEKLVQTVRD | ubiquitination | [1] | | 333 | LKQEHIRKRREEYIS | ubiquitination | [1] | | 1060 | KLDPNLLKTIEAGIG | ubiquitination | [1] | | 1100 | EPLDTIFKQKGYSDE | ubiquitination | [1] | | 1102 | LDTIFKQKGYSDEIY | ubiquitination | [1] | | 1207 | LSPVETWKGGIDNPA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | GTPase-activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of RASA1/p120GAP. |
Sequence Annotation | DOMAIN 267 325 FF 1.
DOMAIN 366 420 FF 2.
DOMAIN 427 481 FF 3.
DOMAIN 482 548 FF 4.
DOMAIN 1261 1448 Rho-GAP.
MOD_RES 550 550 Nitrated tyrosine (By similarity).
MOD_RES 765 765 Phosphoserine (By similarity).
MOD_RES 951 951 Phosphoserine (By similarity).
MOD_RES 968 968 Phosphoserine (By similarity).
MOD_RES 1115 1115 Phosphoserine (By similarity).
MOD_RES 1194 1194 Phosphoserine (By similarity).
MOD_RES 1201 1201 Phosphoserine (By similarity).
MOD_RES 1217 1217 Phosphoserine (By similarity). |
Keyword | Complete proteome; Cytoplasm; GTPase activation; Membrane; Nitration; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1501 AA |
Protein Sequence | MMAKNKEPRP PSYTVSVVGL SGTEKDKGNC GVGKSCLCNR FVRSKADEYY PEHTSVLSTI 60
DFGGRVVNND HFLYWGDITQ NGEDGVECKI HVIEQTEFID DQTFLPHRST NLQPYIKRAA 120
ASKLQSAEKL MYICTDQLGL EQDFEQKQMP EGKLNVDGFL LCIDVSQGCN RKFDDQLKFV 180
NNLFVQLSKS KKPVIIAATK CDECVDHYLR EVQAFASNKK NLLVVETSAR FNVNIETCFT 240
ALVQMLDKTR GKPKIIPYLD AYKTQRQLVV TATDKFEKLV QTVRDYHATW KTVSNKLKNH 300
PDYEEYINLE GTRKARNTFS KHIEQLKQEH IRKRREEYIS TLPRAFNTLL PDLEEIEHLN 360
WLEALKLMEK RADFQLCFVV LEKTPWDETD HIDKINDRRI PFDLLSTLEA EKVYQNHVQH 420
LISEKRRIEM KEKFKKTLEK IQFISPGQPW EEVMCFVMED EAFKYITEAD SKEVYGRHQR 480
EIVEKAKEEF QEMLFEHSEL FYDLDLNATP SSDKMSEIHT VLSEEPRYKA LQKLAPDRES 540
LLLKHIGFVY HPTKETCLSG QYCTDIKVEN LLATSLLEMD HNRVRLYHDS TNIDKVNLFI 600
LGKDGLAQEL ANEIRTQSTD DEYALDGKIY ELDLRPVDAK SPYILSQLWT AAFKPHGCFC 660
VFNSIESLSF IGEFIGKIRT EASQIRKDKY MTNLPFTLIL ANQRDSISKN LPILRHQGQQ 720
LANKLQCPFV DVPTGTYPRK FNESQIKQAL RGVLESVKHN LDVVSPVPIN KDVSEADLRI 780
VMCAMCGDPF SVDLILSPFL DSHSCSAAQA GQNNSLMLDK IIGEKRRRIQ ITILSYHSSI 840
GVRKDELVHG YILVYSAKRK ASMGMLRAFL SEVQDTIPVQ LVAVTDSQAD FFENEAIKEL 900
MTEGEHIATE ITAKFTALYS LSQYHRQTEV FTLFFSDVLE KKNMIENSYL SDNTRESTHQ 960
SEDVFLPSPR DCFPYNNYPD SDDDTEAPPP YSPIGDDVQL LPTPSDRSRY RLDLEGNEYP 1020
VHSTPNCHDH ERNHKVPPPI KPKPVVPKTN VKKLDPNLLK TIEAGIGKNP RKQTSRVPLA 1080
HPEDMDSSDN YVEPLDTIFK QKGYSDEIYV VPDDSQNRII KIRNSFVNNT QGDEENGFSD 1140
PQKVMESVGL QNININLKLC LVKPSHTTEE HTQMQAMMRL SLLPKKRKGR HRGSEEDPLL 1200
SPVETWKGGI DNPAITSDQE VDDKKIKKKT HKVKEDKKQK KKTKTFNPPT RRNWESNYFG 1260
MPLQDLVTAE KPIPLFVEKC VEFIEDTGLC TEGLYRVSGN KTDQDNIQKQ FDQDHNINLA 1320
SMEVTVNAVA GALKAFFADL PDPLIPYSLH PELLEAAKIP DKTERFHALK EIVKKFHPVN 1380
YDVFRYVITH LNRVSQQNKI NLMTADNLSI CFWPTLMRPD FENREFLSTT KIHQSVVETF 1440
IQQCQFFFYN GEIVETANTV APPPTSNPGQ LVESMVPLQL PPPLQPQLIQ PQLQTDPLGI 1500
I 1501 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0005525; F:GTP binding; IEA:InterPro. GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. GO:0030335; P:positive regulation of cell migration; IMP:MGI. GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. GO:0002053; P:positive regulation of mesenchymal cell proliferation; IMP:MGI. GO:0008361; P:regulation of cell size; IMP:MGI. GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |