| Tag | Content |
|---|
| CPLM ID | CPLM-021196 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Disintegrin and metalloproteinase domain-containing protein 19 |
Protein Synonyms/Alias | ADAM 19; Meltrin-beta; Metalloprotease and disintegrin dendritic antigen marker; MADDAM |
Gene Name | ADAM19 |
Gene Synonyms/Alias | MLTNB; FKSG34 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 288 | SFLSWRRKLLAQKYH | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). |
Sequence Annotation | DOMAIN 210 408 Peptidase M12B.
DOMAIN 416 502 Disintegrin.
DOMAIN 650 682 EGF-like.
MOTIF 130 137 Cysteine switch (By similarity).
MOTIF 833 844 SH3-binding (Potential).
ACT_SITE 346 346 By similarity.
METAL 132 132 Zinc; in inhibited form (By similarity).
METAL 345 345 Zinc; catalytic (By similarity).
METAL 349 349 Zinc; catalytic (By similarity).
METAL 355 355 Zinc; catalytic (By similarity).
CARBOHYD 144 144 N-linked (GlcNAc...) (Potential).
CARBOHYD 444 444 N-linked (GlcNAc...) (Potential).
CARBOHYD 447 447 N-linked (GlcNAc...) (Potential).
CARBOHYD 645 645 N-linked (GlcNAc...) (Potential).
DISULFID 320 403 By similarity.
DISULFID 360 387 By similarity.
DISULFID 361 370 By similarity.
DISULFID 474 494 By similarity.
DISULFID 654 664 By similarity.
DISULFID 658 670 By similarity.
DISULFID 672 681 By similarity. |
Keyword | Alternative splicing; Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein; Hydrolase; Membrane; Metal-binding; Metalloprotease; Polymorphism; Protease; Reference proteome; SH3-binding; Signal; Transmembrane; Transmembrane helix; Zinc; Zymogen. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 955 AA |
Protein Sequence | MPGGAGAARL CLLAFALQPL RPRAAREPGW TRGSEEGSPK LQHELIIPQW KTSESPVREK 60
HPLKAELRVM AEGRELILDL EKNEQLFAPS YTETHYTSSG NPQTTTRKLE DHCFYHGTVR 120
ETELSSVTLS TCRGIRGLIT VSSNLSYVIE PLPDSKGQHL IYRSEHLKPP PGNCGFEHSK 180
PTTRDWALQF TQQTKKRPRR MKREDLNSMK YVELYLVADY LEFQKNRRDQ DATKHKLIEI 240
ANYVDKFYRS LNIRIALVGL EVWTHGNMCE VSENPYSTLW SFLSWRRKLL AQKYHDNAQL 300
ITGMSFHGTT IGLAPLMAMC SVYQSGGVNM DHSENAIGVA ATMAHEMGHN FGMTHDSADC 360
CSASAADGGC IMAAATGHPF PKVFNGCNRR ELDRYLQSGG GMCLSNMPDT RMLYGGRRCG 420
NGYLEDGEEC DCGEEEECNN PCCNASNCTL RPGAECAHGS CCHQCKLLAP GTLCREQARQ 480
CDLPEFCTGK SPHCPTNFYQ MDGTPCEGGQ AYCYNGMCLT YQEQCQQLWG PGARPAPDLC 540
FEKVNVAGDT FGNCGKDMNG EHRKCNMRDA KCGKIQCQSS EARPLESNAV PIDTTIIMNG 600
RQIQCRGTHV YRGPEEEGDM LDPGLVMTGT KCGYNHICFE GQCRNTSFFE TEGCGKKCNG 660
HGVCNNNQNC HCLPGWAPPF CNTPGHGGSI DSGPMPPESV GPVVAGVLVA ILVLAVLMLM 720
YYCCRQNNKL GQLKPSALPS KLRQQFSCPF RVSQNSGTGH ANPTFKLQTP QGKRKVINTP 780
EILRKPSQPP PRPPPDYLRG GSPPAPLPAH LSRAARNSPG PGSQIERTES SRRPPPSRPI 840
PPAPNCIVSQ DFSRPRPPQK ALPANPVPGR RSLPRPGGAS PLRPPGAGPQ QSRPLAALAP 900
KVSPREALKV KAGTRGLQGG RCRVEKTKQF MLLVVWTELP EQKPRAKHSC FLVPA 955 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0004222; F:metalloendopeptidase activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0007507; P:heart development; IEA:Compara. GO:0006509; P:membrane protein ectodomain proteolysis; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |