CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013515
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative heat shock protein HSP 90-beta 4 
Protein Synonyms/Alias
  
Gene Name
 HSP90AB4P 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
161TKVILHLKEDQTEYLubiquitination[1]
414FVEQEWKKGFEVIYMmethylation[2]
446KSLLSVTKEGLELPEubiquitination[3]
476ENLCRLMKEILDKKVubiquitination[1, 4]
482MKEILDKKVERVTISubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins (By similarity). 
Sequence Annotation
 BINDING 22 22 ATP (By similarity).
 BINDING 83 83 ATP (By similarity).
 BINDING 109 109 ATP; via amide nitrogen (By similarity).  
Keyword
 ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 505 AA 
Protein Sequence
MSLIINTFYS NKEIFLQELI SNASDALDKI RYESLTDPSK LDGGKELKID IIPNPRECIL 60
TLVNTGIGMT KADLINNLGA IAKSGTEAFM EAFQSCAEIS MIGQFGVGFY SAYLVAEKVA 120
ITKHNDEEQY SWVSSAGSSF TLHVDHGEPI DRDTKVILHL KEDQTEYLEE RWVKEVVKKH 180
PQFIGCLIAV YLEKEPEKEI SDDEEEKGEK EEEDKDDKEK PKTEDVGSDE EDDTDKNNKK 240
KTKKIKEKYT DREELNQTKP IWTRNPDDIT QEECGEFYKS LTSAWEDHLA VKQFPVEEQE 300
ENEQLCVHHV WIMDSFDDLM PEYVGFVRED KENNKKLDEV FSKISWLGIH EDSINWRHLS 360
ELLWSHTFQS GDEMTSLSEY VSCMKEAQKS ICDIIGECKE QVANSAFVEQ EWKKGFEVIY 420
MSEPIDEYCV QQLKEFDGKS LLSVTKEGLE LPEDEEEKKI MEESNVKFEN LCRLMKEILD 480
KKVERVTISS RLVSSPCRIV TSTYS 505 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 
Interpro
 IPR003594; HATPase_ATP-bd.
 IPR001404; Hsp90.
 IPR020575; Hsp90_N.
 IPR020568; Ribosomal_S5_D2-typ_fold. 
Pfam
 PF02518; HATPase_c
 PF00183; HSP90 
SMART
 SM00387; HATPase_c 
PROSITE
  
PRINTS
 PR00775; HEATSHOCK90.