CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026434
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lysine--tRNA ligase 
Protein Synonyms/Alias
 Lysyl-tRNA synthetase 
Gene Name
 Kars 
Gene Synonyms/Alias
 rCG_51508 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
204EFVHINNKLRRGDIIacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Aminoacyl-tRNA synthetase; Complete proteome; Ligase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 626 AA 
Protein Sequence
MLMQAAVRLV RGSLRQTSWA EWGQRELRLG QLAPFTTLRK DKPLSDRRSE LKRRLKAEKK 60
LAEKEAKQKE LSEKQLNQTT AAAATNHTAD NGVGAEEETL DPNQYYKIRS QAVQQLKVSG 120
EDPYPHKFHV DISLTQFIQE YSHLQPGDHL TDITLKVAGR IHAKRASGGK LIFYDLRGEG 180
VKLQVMANSR NYKSEEEFVH INNKLRRGDI IGVEGNPGKT KKGELSIVPR EMTLLSPCLH 240
MLPHLHFGLK DKETRYRQRY LDLILNDFVR QKFIIRSKII TYIRSFLDEL GFLEIETPMM 300
NIIPGGAVAK PFITYHNELD MNLYMRIAPE LYHKMLVVGG IDRVYEIGRQ FRNEGIDLTH 360
NPEFTTCEFY MAYADYHDLM EITEKMLSGM VRSITGSYKI TYHPDGPEGQ AYEIDFTPPF 420
RRISMVEELE KVLGVKLPET SLFETEETRK ILDDICVARA VECPPPRTTA RLLDKLVGEF 480
LEVTCISPTF ICDHPQIMSP LAKWHRCKEG LTERFELFVM KKEICNAYTE LNDPVRQRQL 540
FEEQAKAKAA GDDEAMFIDE NFCTALEYGL PPTAGWGMGI DRVTMFLTDS NNIKEVLLFP 600
AMKPEDKKET ATATETPEST EASPSV 626 
Gene Ontology
 GO:0017101; C:aminoacyl-tRNA synthetase multienzyme complex; IDA:RGD.
 GO:0015630; C:microtubule cytoskeleton; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0016597; F:amino acid binding; IDA:RGD.
 GO:0005524; F:ATP binding; IDA:RGD.
 GO:0004824; F:lysine-tRNA ligase activity; IDA:RGD.
 GO:0000049; F:tRNA binding; IDA:RGD.
 GO:0015966; P:diadenosine tetraphosphate biosynthetic process; IDA:RGD.
 GO:0006430; P:lysyl-tRNA aminoacylation; IDA:RGD. 
Interpro
 IPR004364; aa-tRNA-synt_II.
 IPR018150; aa-tRNA-synt_II-like.
 IPR006195; aa-tRNA-synth_II.
 IPR002313; Lys-tRNA-ligase_II.
 IPR018149; Lys-tRNA-synth_II_C.
 IPR012340; NA-bd_OB-fold.
 IPR004365; NA-bd_OB_tRNA-helicase. 
Pfam
 PF00152; tRNA-synt_2
 PF01336; tRNA_anti 
SMART
  
PROSITE
 PS50862; AA_TRNA_LIGASE_II 
PRINTS
 PR00982; TRNASYNTHLYS.