CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040729
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Bax inhibitor 1 
Protein Synonyms/Alias
  
Gene Name
 TMBIM6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
65TMNIFDRKINFDALLubiquitination[1, 2, 3]
73INFDALLKFSHITPSubiquitination[2]
86PSTQQHLKKVYASFAubiquitination[2]
87STQQHLKKVYASFALubiquitination[2]
288MILAMNEKDKKKEKKubiquitination[4]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 295 AA 
Protein Sequence
MSHSSVTREA PQLLSQRQRR EVRGVWGWGC LPGPRGGPAL FGLVTFGQSG DCCTDSGTMN 60
IFDRKINFDA LLKFSHITPS TQQHLKKVYA SFALCMFVAA AGAYVHMVTH FIQAGLLSAL 120
GSLILMIWLM ATPHSHETEQ KRLGLLAGFA FLTGVGLGPA LEFCIAVNPS ILPTAFMGTA 180
MIFTCFTLSA LYARRRSYLF LGGILMSALS LLLLSSLGNV FFGSIWLFQA NLYVGLVVMC 240
GFVLFDTQLI IEKAEHGDQD YIWHCIDLFL DFITVFRKLM MILAMNEKDK KKEKK 295 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro. 
Interpro
 IPR006213; Bax_inhbtr1_CS.
 IPR006214; Bax_inhibitor_1-related. 
Pfam
 PF01027; Bax1-I 
SMART
  
PROSITE
 PS01243; BI1 
PRINTS