UniProt Accession

 VE2_HPV16; P03120; Q71BI4 

Genbank Protein ID

 K02718; AF536179 

Genbank Nucleotide ID

 AAA46941.1; AAQ10715.1 

Protein Name

 Regulatory protein E2 

Protein Synonyms/Alias

  

Gene Name

 E2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Human papillomavirus type 16 

NCBI Taxa ID

 333760 

Lysine Modification

Position	Peptide	Type	References
292	TTPIVHLKGDANTLK	sumoylation	[1]

Reference

 [1] Modification of papillomavirus E2 proteins by the small ubiquitin-like modifier family members (SUMOs).
 Wu YC, Roark AA, Bian XL, Wilson VG.
 Virology. 2008 Sep 1;378(2):329-38. [PMID: 18619639] 

Functional Description

 Plays an accessory role in initiation of DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex. 

Sequence Annotation

  

Keyword

 3D-structure; Activation of host caspases by virus; Activator; Complete proteome; DNA replication; DNA-binding; Early protein; Host nucleus; Host-virus interaction; Modulation of host cell apoptosis by virus; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 365 AA 

Protein Sequence

Gene Ontology

 GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
 GO:0039651; P:induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process; IEA:UniProtKB-KW.
 GO:0006275; P:regulation of DNA replication; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000427; Papillomavirus_E2_C.
 IPR001866; Papillomavirus_E2_N. 

Pfam

 PF00511; PPV_E2_C
 PF00508; PPV_E2_N 

SMART

  

PROSITE

  

PRINTS