UniProt Accession

 CRL_ECOLI; P24251; P77629; Q47242; Q47585 

Genbank Protein ID

 V00316; X67207; U70214; U00096; AP009048; M13422 

Genbank Nucleotide ID

 CAA23606.1; CAA47646.1; AAB08660.1; AAC73344.1; BAA77909.2; AAA23930.1 

Protein Name

 Sigma factor-binding protein Crl 

Protein Synonyms/Alias

 Curlin genes transcriptional activatory protein 

Gene Name

 crl 

Gene Synonyms/Alias

 b0240; JW0230 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
14	HPKSRLIKKFTALGP	acetylation	[1]
15	PKSRLIKKFTALGPY	acetylation	[1, 2]
78	YQFGLFDKAGDWKSV	acetylation	[1]
83	FDKAGDWKSVPVKDT	acetylation	[1]
88	DWKSVPVKDTEVVER	acetylation	[1, 2]
106	TLREFHEKLRELLTT	acetylation	[1]
117	LLTTLNLKLEPADDF	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes, such as the csgBAC operon encoding the subunits of curli proteins. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32. 

Sequence Annotation

 REGION 99 122 Essential for activity.  

Keyword

 Activator; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 133 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016987; F:sigma factor activity; IEA:HAMAP.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR009986; Tscrpt_reg_Crl. 

Pfam

 PF07417; Crl 

SMART

  

PROSITE

  

PRINTS