UniProt Accession

 RTN4_HUMAN; Q9NQC3; O94962; Q7L7Q5; Q7L7Q6; Q7L7Q8; Q8IUA4; Q96B16; Q9BXG5; Q9H212; Q9H3I3; Q9UQ42; Q9Y293; Q9Y2Y7; Q9Y5U6 

Genbank Protein ID

 AF087901; AF148537; AF148538; AJ251383; AJ251384; AJ251385; AB040462; AB040463; AF333336; AY102285; AY102285; AY102285; AY102285; AY102285; AY102276; AY102277; AY102278; AY102279; AY123245; AY123246; AY123247; AY123248; AY123249; AY123250; AB015639; AF077050; AF132047; AF132048; AF320999; AB020693; AF125103; AF177332; AC013414; AC092461; AC093165; CH471053; CH471053; CH471053; CH471053; CH471053; CH471053; CH471053; CH471053; CH471053; CH471053; CH471053; CH471053; CH471053; BC001035; BC007109; BC010737; BC012619; BC014366; BC016165; BC026788; BC068991; BC150182; BC152425; BC152555; AF063601 

Genbank Nucleotide ID

 AAG12205.1; AAG12176.1; AAG12177.1; CAB99248.1; CAB99249.1; CAB99250.1; BAB18927.1; BAB18928.1; AAK20831.1; AAM64240.1; AAM64241.1; AAM64242.1; AAM64243.1; AAM64244.1; AAM64245.1; AAM64246.1; AAM64247.1; AAM64248.1; AAM64249.1; AAM64250.1; AAM64251.1; AAM64252.1; AAM64253.1; AAM64254.1; BAA83712.1; AAD27783.1; AAD31021.1; AAD31022.1; AAG40878.1; BAA74909.2; AAD39920.1; AAG17976.1; EAX00115.1; EAX00116.1; EAX00117.1; EAX00118.1; EAX00119.1; EAX00121.1; EAX00122.1; EAX00123.1; EAX00124.1; EAX00125.1; EAX00127.1; EAX00130.1; EAX00132.1; AAH01035.1; AAH07109.1; AAH10737.1; AAH12619.1; AAH14366.1; AAH16165.1; AAH26788.1; AAH68991.1; AAI50183.1; AAI52426.1; AAI52556.1; AAG43160.1 

Protein Name

 Reticulon-4 

Protein Synonyms/Alias

 Foocen; Neurite outgrowth inhibitor; Nogo protein; Neuroendocrine-specific protein; NSP; Neuroendocrine-specific protein C homolog; RTN-x; Reticulon-5 

Gene Name

 RTN4 

Gene Synonyms/Alias

 KIAA0886; NOGO; My043; SP1507 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
58	ELEVLERKPAAGLSA	ubiquitination	[1]
352	HYLGLANKNVKDAMA	ubiquitination	[1]
355	GLANKNVKDAMAKIQ	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. 

Sequence Annotation

 DOMAIN 1005 1192 Reticulon.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 7 7 Phosphoserine.
 MOD_RES 15 15 Phosphoserine.
 MOD_RES 107 107 Phosphoserine.
 MOD_RES 152 152 Phosphoserine (By similarity).
 MOD_RES 181 181 Phosphoserine.
 MOD_RES 182 182 Phosphoserine.
 MOD_RES 188 188 Phosphothreonine (By similarity).
 MOD_RES 361 361 Phosphoserine (By similarity).
 MOD_RES 446 446 Phosphoserine (By similarity).
 MOD_RES 860 860 Phosphoserine (By similarity).
 MOD_RES 863 863 Phosphoserine (By similarity).
 MOD_RES 889 889 Phosphotyrosine (By similarity).
 MOD_RES 1104 1104 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Membrane; Neurogenesis; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1192 AA 

Protein Sequence

Gene Ontology

 GO:0042995; C:cell projection; IEA:Compara.
 GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005635; C:nuclear envelope; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0006915; P:apoptotic process; NAS:UniProtKB.
 GO:0007413; P:axonal fasciculation; ISS:UniProtKB.
 GO:0060317; P:cardiac epithelial to mesenchymal transition; IEA:Compara.
 GO:0021801; P:cerebral cortex radial glia guided migration; ISS:UniProtKB.
 GO:0071786; P:endoplasmic reticulum tubular network organization; IMP:UniProtKB.
 GO:0030517; P:negative regulation of axon extension; IDA:UniProtKB.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0042981; P:regulation of apoptotic process; NAS:UniProtKB.
 GO:2000172; P:regulation of branching morphogenesis of a nerve; ISS:UniProtKB.
 GO:0030334; P:regulation of cell migration; IDA:MGI. 

Interpro

 IPR003388; Reticulon. 

Pfam

 PF02453; Reticulon 

SMART

  

PROSITE

 PS50845; RETICULON 

PRINTS