CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009915
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nodal modulator 3 
Protein Synonyms/Alias
 pM5 protein 3 
Gene Name
 NOMO3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
66YTKHGTLKYQTDCAPubiquitination[1]
138VNGKVLSKGQPLGPAubiquitination[1, 2]
159RNTGTEAKIQSTVTQubiquitination[1, 2, 3]
170TVTQPGGKFAFFKVLubiquitination[1, 2]
175GGKFAFFKVLPGDYEubiquitination[1]
193THPTWALKEASTTVRubiquitination[1, 2]
231RSDGEPMKGVKFLLFubiquitination[1]
356VTLNNQIKVKTKADGubiquitination[1, 2]
424IRFPDTVKQMNKYKVubiquitination[1]
430VKQMNKYKVVLSSQDubiquitination[1]
438VVLSSQDKDKSLVTVubiquitination[1]
440LSSQDKDKSLVTVETubiquitination[1]
463KANPGTYKVQVMVPEubiquitination[1]
554FDNVLPGKYKISIMHubiquitination[1, 2]
630VNRFCLSKPGVYKVTubiquitination[1]
635LSKPGVYKVTPRSCHubiquitination[1]
700ALVLGPLKSVQELRRubiquitination[1, 2]
762YWARSGEKITVTPSSubiquitination[1]
770ITVTPSSKELLFYPPubiquitination[1, 2]
927SPGQYYFKPMMKEFRubiquitination[1]
931YYFKPMMKEFRFEPSubiquitination[1]
1019CVYHVQLKAEGNDHIubiquitination[1]
1079TLWVKLYKSENLDNPubiquitination[2]
1211NSGPEDAKRQAKKQKubiquitination[1, 2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 
Functional Description
 May antagonize Nodal signaling (By similarity). 
Sequence Annotation
 MOD_RES 1205 1205 Phosphoserine (By similarity).
 CARBOHYD 50 50 N-linked (GlcNAc...) (Potential).
 CARBOHYD 218 218 N-linked (GlcNAc...) (Potential).
 CARBOHYD 618 618 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1222 AA 
Protein Sequence
MLVGQGAGPL GPAVVTAAVV LLLSGVGPAH GSEDIVVGCG GFVKSDVEIN YSLIEIKLYT 60
KHGTLKYQTD CAPNNGYFMI PLYDKGDFIL KIEPPLGWSF EPTTVELHVD GVSDICTKGG 120
DINFVFTGFS VNGKVLSKGQ PLGPAGVQVS LRNTGTEAKI QSTVTQPGGK FAFFKVLPGD 180
YEILATHPTW ALKEASTTVR VTNSNANAAS PLIVAGYNVS GSVRSDGEPM KGVKFLLFSS 240
LVTKEDVLGC NVSPVPGFQP QDESLVYLCY TVSREDGSFS FYSLPSGGYT VIPFYRGERI 300
TFDVAPSRLD FTVEHDSLKI EPVFHVMGFS VTGRVLNGPE GDGVPEAVVT LNNQIKVKTK 360
ADGSFRLENI TTGTYTIHAQ KEHLYFETVT IKIAPNTPQL ADIVATGFSV CGQISIIRFP 420
DTVKQMNKYK VVLSSQDKDK SLVTVETDAH GSFCFKANPG TYKVQVMVPE AETRAGLTLK 480
PQTFPLTVTD RPVMDVAFVQ FLASVSGKVS CLDTCGDLLV TLQSLSRQGE KRSLQLSGKV 540
NAMTFTFDNV LPGKYKISIM HEDWCWKNKS LEVEVLEDDV SAVEFRQTGY MLRCSLSHAI 600
TLEFYQDGNG RENVGIYNLS KGVNRFCLSK PGVYKVTPRS CHRFEQAFYT YDTSSPSILT 660
LTAIRHHVLG TITTDKMMDV TVTIKSSIDS EPALVLGPLK SVQELRREQQ LAEIEARRQE 720
REKNGNEEGE ERMTKPPVQE MVDELQGPFS YDFSYWARSG EKITVTPSSK ELLFYPPSME 780
AVVSGESCPG KLIEIHGKAG LFLEGQIHPE LEGVEIVISE KGASSPLITV FTDDKGAYSV 840
GPLHSDLEYT VTSQKEGYVL TAVEGTIGDF KAYALAGVSF EIKAEDDQPL PGVLLSLSGG 900
LFRSNLLTQD NGILTFSNLS PGQYYFKPMM KEFRFEPSSQ MIEVQEGQNL KITITGYRTA 960
YSCYGTVSSL NGEPEQGVAM EAVGQNDCSI YGEDTVTDEE GKFRLRGLLP GCVYHVQLKA 1020
EGNDHIERAL PHHRVIEVGN NDIDDVNIIV FRQINQFDLS GNVITSSEYL PTLWVKLYKS 1080
ENLDNPIQTV SLGQSLFFHF PPLLRDGENY VVLLDSTLPR SQYDYILPQV SFTAVGYHKH 1140
ITLIFNPTRK LPEQDIAQGS YIALPLTLLV LLAGYNHDKL IPLLLQLTSR LQGVGALGQA 1200
ASDNSGPEDA KRQAKKQKTR RT 1222 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030246; F:carbohydrate binding; IEA:InterPro. 
Interpro
 IPR013784; Carb-bd-like_fold.
 IPR008969; CarboxyPept-like_regulatory.
 IPR014766; CarboxyPept_regulatory_dom.
 IPR013783; Ig-like_fold.
 IPR027064; NOMO. 
Pfam
  
SMART
  
PROSITE
  
PRINTS