UniProt Accession

 PHS_MOUSE; P61458; P70519; P80095; Q9D930 

Genbank Protein ID

 M83741; AK007401; BC024354 

Genbank Nucleotide ID

 BAB25014.1; AAH24354.1 

Protein Name

 Pterin-4-alpha-carbinolamine dehydratase 

Protein Synonyms/Alias

 PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD 

Gene Name

 Pcbd1 

Gene Synonyms/Alias

 Dcoh; Pcbd 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
41	IFKQFHFKDFNRAFG	ubiquitination	[1]
59	RVALQAEKLDHHPEW	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity). 

Sequence Annotation

 REGION 61 63 Substrate binding (By similarity).
 REGION 78 81 Substrate binding (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Activator; Complete proteome; Cytoplasm; Direct protein sequencing; Lyase; Nucleus; Reference proteome; Tetrahydrobiopterin biosynthesis; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 104 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IPI:MGI.
 GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; IEA:EC.
 GO:0004505; F:phenylalanine 4-monooxygenase activity; IDA:MGI.
 GO:0003713; F:transcription coactivator activity; ISO:MGI.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISO:MGI.
 GO:0051291; P:protein heterooligomerization; IPI:MGI.
 GO:0051289; P:protein homotetramerization; IPI:MGI.
 GO:0043496; P:regulation of protein homodimerization activity; ISO:MGI.
 GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001533; Trans/pterin_deHydtase. 

Pfam

 PF01329; Pterin_4a 

SMART

  

PROSITE

  

PRINTS