CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031122
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Magnesium transporter MRS2 homolog, mitochondrial 
Protein Synonyms/Alias
 cDNA FLJ52725, highly similar to Magnesium transporter MRS2L, mitochondrial 
Gene Name
 MRS2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
90APVFTVTKFDKQGNVacetylation[1]
90APVFTVTKFDKQGNVubiquitination[2]
93FTVTKFDKQGNVTSFubiquitination[3]
284SDPQVFEKSSAGIDHubiquitination[4]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 446 AA 
Protein Sequence
MECLRSLPCL LPRAMRLPRR TLCALALDVT SVGPPVAACG RRANLIGRSR AAQLCGPDRL 60
RVAGEVHRFR TSDVSQATLA SVAPVFTVTK FDKQGNVTSF ERKKTELYQE LGLQARDLRF 120
QHVMSITVRN NRIIMRMEKY SLLLESVASI LQNSVSFMER QTEQWLFREL PSQLSGEGQL 180
VTYPLPFEFR AIEALLQYWI NTLQGKLSIL QPLILETLDA LVDPKHSSVD RSKLHILLQN 240
GKSLSELETD IKIFKESILE ILDEEELLEE LCVSKWSDPQ VFEKSSAGID HAEEMELLLE 300
NYYRLADDLS NAARELRVLI DDSQSIIFIN LDSHRNVMMR LNLQLTMGTF SLSLFGLMGV 360
AFGMNLESSL EEDHRIFWLI TGIMFMGSGL IWRRLLSFLG RQLEAPLPPM MASLPKKTLL 420
ADRSMELKNS LRLDGLGSGR SILTNR 446 
Gene Ontology
 GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro. 
Interpro
 IPR026573; MRS2/LPE10. 
Pfam
  
SMART
  
PROSITE
  
PRINTS