UniProt Accession

 PP12_DROME; P12982; Q4PIY5; Q9VG75 

Genbank Protein ID

 X15583; S47852; AE014297; AY061063 

Genbank Nucleotide ID

 CAA33609.1; AAB23957.1; AAF54810.1; AAL28611.1 

Protein Name

 Serine/threonine-protein phosphatase alpha-2 isoform 

Protein Synonyms/Alias

  

Gene Name

 Pp1-87B 

Gene Synonyms/Alias

 CG5650 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
236	VVAKFLQKHEFDLIC	acetylation	[1]
258	DGYEFFAKRMLVTLF	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Is essential for the regulation of mitotic chromosomal segregation as well as regulation of chromatin condensation during interphase. 

Sequence Annotation

 ACT_SITE 123 123 Proton donor (By similarity).
 METAL 62 62 Iron (By similarity).
 METAL 64 64 Iron (By similarity).
 METAL 90 90 Iron (By similarity).
 METAL 90 90 Manganese (By similarity).
 METAL 122 122 Manganese (By similarity).
 METAL 171 171 Manganese (By similarity).
 METAL 246 246 Manganese (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Hydrolase; Iron; Manganese; Metal-binding; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 302 AA 

Protein Sequence

Gene Ontology

 GO:0005700; C:polytene chromosome; IDA:FlyBase.
 GO:0000164; C:protein phosphatase type 1 complex; ISS:FlyBase.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0017018; F:myosin phosphatase activity; IDA:FlyBase.
 GO:0008344; P:adult locomotory behavior; IMP:FlyBase.
 GO:0007411; P:axon guidance; IMP:FlyBase.
 GO:0030261; P:chromosome condensation; IMP:FlyBase.
 GO:0007080; P:mitotic metaphase plate congression; IMP:FlyBase.
 GO:0000022; P:mitotic spindle elongation; IMP:FlyBase.
 GO:0008355; P:olfactory learning; IMP:FlyBase.
 GO:0048477; P:oogenesis; IMP:FlyBase.
 GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.
 GO:0006470; P:protein dephosphorylation; IMP:FlyBase.
 GO:0051225; P:spindle assembly; IMP:FlyBase.
 GO:0008542; P:visual learning; IMP:FlyBase. 

Interpro

 IPR004843; Metallo_PEstase_dom.
 IPR006186; Ser/Thr-sp_prot-phosphatase. 

Pfam

 PF00149; Metallophos 

SMART

 SM00156; PP2Ac 

PROSITE

 PS00125; SER_THR_PHOSPHATASE 

PRINTS

 PR00114; STPHPHTASE.