CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025004
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TTC7A protein 
Protein Synonyms/Alias
 Tetratricopeptide repeat protein 7A 
Gene Name
 TTC7A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
4****MAAKGAHGSYLubiquitination[1]
79ALLEQCLKENHAKIKubiquitination[1]
84CLKENHAKIKDSMPLubiquitination[1]
103EPKMSEAKNYLSSILubiquitination[1]
157DDMSMENKPLYQMRLubiquitination[1]
172LSEAFVIKGLSLERLubiquitination[1, 2]
259LKKGNIVKGMRELREubiquitination[1]
280TKATQNFKVMAAKHLubiquitination[1]
326FATQALRKPHLYEGDubiquitination[1]
516KQDELHRKALQTLERubiquitination[1]
680GEGLTMKKQSGMHLTubiquitination[1]
782RGRLAEVKGNLEEAKubiquitination[1]
789KGNLEEAKQLYKEALubiquitination[1, 2]
793EEAKQLYKEALTVNPubiquitination[1]
824GHKSLAQKVLRDAVEubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 882 AA 
Protein Sequence
MAAKGAHGSY LKVESELERC RAEGHWDRMP ELVRQLQTLS MPGGGGNRRG SPSAAFTFPD 60
TDDFGKLLLA EALLEQCLKE NHAKIKDSMP LLEKNEPKMS EAKNYLSSIL NHGRLSPQYM 120
CEAMLILGKL HYVEGSYRDA ISMYARAGID DMSMENKPLY QMRLLSEAFV IKGLSLERLP 180
NSIASRFRLT EREEEVITCF ERASWIAQVF LQELEKTTNN STSRHLKGCH PLDYELTYFL 240
EAALQSAYVK NLKKGNIVKG MRELREVLRT VETKATQNFK VMAAKHLAGV LLHSLSEECY 300
WSPLSHPLPE FMGKEESSFA TQALRKPHLY EGDNLYCPKD NIEEALLLLL ISESMATRDV 360
VLSRVPEQEE DRTVSLQNAA AIYDLLSITL GRRGQYVMLS ECLERAMKFA FGEFHLWYQV 420
ALSMVACGKS AYAVSLLREC VKLRPSDPTV PLMAAKVCIG SLRWLEEAEH FAMMVISLGE 480
EAGEFLPKGY LALGLTYSLQ ATDATLKSKQ DELHRKALQT LERAQQLAPS DPQVILYVSL 540
QLALVRQISS AMEQLQEALK VRKDDAHALH LLALLFSAQK HHQHALDVVN MAITEHPENF 600
NLMFTKVKLE QVLKGPEEAL VTCRQVLRLW QTLYSFSQLG DFRSPEGFQT PQRNICNSEI 660
YRGGGLEKDG SFGEGLTMKK QSGMHLTLPD AHDADSGSRR ASSIAASRLE EAMSELTMPS 720
SVLKQGPMQL WTTLEQIWLQ AAELFMEQQH LKEAGFCIQE AAGLFPTSHS VLYMRGRLAE 780
VKGNLEEAKQ LYKEALTVNP DGVRIMHSLG LMLSRLGHKS LAQKVLRDAV ERQSTCHEAW 840
QGLGEVLQAQ GQNEAAVDCF LTALELEASS PVLPFSIIPR EL 882 
Gene Ontology
  
Interpro
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat.
 IPR026900; Ttc7. 
Pfam
 PF00515; TPR_1 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS