UniProt Accession

 ANM1_MOUSE; Q9JIF0; Q99LS4 

Genbank Protein ID

 AF232716; AF232717; BC002249 

Genbank Nucleotide ID

 AAF37292.1; AAF37293.1; AAH02249.1 

Protein Name

 Protein arginine N-methyltransferase 1 

Protein Synonyms/Alias

 Histone-arginine N-methyltransferase PRMT1 

Gene Name

 Prmt1 

Gene Synonyms/Alias

 Hrmt1l2; Mrmt1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
131	DYAVKIVKANKLDHV	ubiquitination	[1]
134	VKIVKANKLDHVVTI	ubiquitination	[1]
233	CIKDVAIKEPLVDVV	ubiquitination	[1]
342	IGMRPNAKNNRDLDF	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. 

Sequence Annotation

 ACT_SITE 162 162 By similarity.
 ACT_SITE 171 171 By similarity.
 BINDING 63 63 S-adenosyl-L-methionine (By similarity).
 BINDING 72 72 S-adenosyl-L-methionine (By similarity).
 BINDING 96 96 S-adenosyl-L-methionine; via carbonyl
 BINDING 118 118 S-adenosyl-L-methionine (By similarity).
 BINDING 147 147 S-adenosyl-L-methionine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Methyltransferase; Nucleus; Reference proteome; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 371 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0016275; F:[cytochrome c]-arginine N-methyltransferase activity; IEA:Compara.
 GO:0044020; F:histone methyltransferase activity (H4-R3 specific); ISS:UniProtKB.
 GO:0035242; F:protein-arginine omega-N asymmetric methyltransferase activity; IEA:Compara.
 GO:0035241; F:protein-arginine omega-N monomethyltransferase activity; IEA:Compara.
 GO:0030519; F:snoRNP binding; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0045653; P:negative regulation of megakaryocyte differentiation; ISS:UniProtKB.
 GO:0031175; P:neuron projection development; IEA:Compara. 

Interpro

 IPR025799; Arg_MeTrfase.
 IPR025714; Methyltranfer_dom. 

Pfam

 PF13847; Methyltransf_31 

SMART

  

PROSITE

  

PRINTS