UniProt Accession

 GATM_MOUSE; Q9D964; A2AK36; Q3U8U4; Q3UAM0; Q3UKD9; Q6IU01 

Genbank Protein ID

 AK007325; AK146052; AK146111; AK151313; AK152069; AL772253; CH466519; BC003879; AY625267 

Genbank Nucleotide ID

 BAB24960.1; BAE26862.1; BAE26909.1; BAE30294.1; BAE30923.1; CAM13305.1; EDL28104.1; AAH03879.1; AAT39893.1 

Protein Name

 Glycine amidinotransferase, mitochondrial 

Protein Synonyms/Alias

 L-arginine:glycine amidinotransferase; Transamidinase 

Gene Name

 Gatm 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
154	IDWSLKYKTPDFEST	ubiquitination	[1]
381	ANEVPIQKMFEKLGI	acetylation	[2]
381	ANEVPIQKMFEKLGI	succinylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. 

Sequence Annotation

 ACT_SITE 254 254 By similarity.
 ACT_SITE 303 303 By similarity.
 ACT_SITE 407 407 Amidino-cysteine intermediate (By
 MOD_RES 385 385 N6-acetyllysine (By similarity).
 MOD_RES 417 417 Phosphothreonine.  

Keyword

 Acetylation; Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 423 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005758; C:mitochondrial intermembrane space; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0015068; F:glycine amidinotransferase activity; IEA:EC.
 GO:0016813; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines; IEA:InterPro.
 GO:0006601; P:creatine biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0009790; P:embryo development; IEA:Compara.
 GO:0046689; P:response to mercury ion; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IEA:Compara.
 GO:0043434; P:response to peptide hormone stimulus; IEA:Compara.
 GO:0042246; P:tissue regeneration; IEA:Compara. 

Interpro

 IPR003198; Amidino_trans. 

Pfam

 PF02274; Amidinotransf 

SMART

  

PROSITE

  

PRINTS