| Tag | Content |
|---|
| CPLM ID | CPLM-023681 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Bile acyl-CoA synthetase |
Protein Synonyms/Alias | BACS; Bile acid-CoA ligase; BA-CoA ligase; BAL; Cholate--CoA ligase; Fatty acid transport protein 5; FATP-5; Fatty-acid-coenzyme A ligase, very long-chain 3; Solute carrier family 27 member 5; Very long-chain acyl-CoA synthetase homolog 2; VLCS-H2; VLCSH2; Very long-chain acyl-CoA synthetase-related protein; VLACS-related; VLACSR |
Gene Name | SLC27A5 |
Gene Synonyms/Alias | ACSB; ACSVL6; FACVL3; FATP5 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 241 | SLEEILPKLQAENIR | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. |
Sequence Annotation | NP_BIND 292 303 AMP (Potential). |
Keyword | ATP-binding; Complete proteome; Endoplasmic reticulum; Fatty acid metabolism; Ligase; Lipid metabolism; Membrane; Nucleotide-binding; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 690 AA |
Protein Sequence | MGVRQQLALL LLLLLLLWGL GQPVWPVAVA LTLRWLLGDP TCCVLLGLAM LARPWLGPWV 60
PHGLSLAAAA LALTLLPARL PPGLRWLPAD VIFLAKILHL GLKIRGCLSR QPPDTFVDAF 120
ERRARAQPGR ALLVWTGPGA GSVTFGELDA RACQAAWALK AELGDPASLC AGEPTALLVL 180
ASQAVPALCM WLGLAKLGCP TAWINPHGRG MPLAHSVLSS GARVLVVDPD LRESLEEILP 240
KLQAENIRCF YLSHTSPTPG VGALGAALDA APSHPVPADL RAGITWRSPA LFIYTSGTTG 300
LPKPAILTHE RVLQMSKMLS LSGATADDVV YTVLPLYHVM GLVVGILGCL DLGATCVLAP 360
KFSTSCFWDD CRQHGVTVIL YVGELLRYLC NIPQQPEDRT HTVRLAMGNG LRADVWETFQ 420
QRFGPIRIWE VYGSTEGNMG LVNYVGRCGA LGKMSCLLRM LSPFELVQFD MEAAEPVRDN 480
QGFCIPVGLG EPGLLLTKVV SQQPFVGYRG PRELSERKLV RNVRQSGDVY YNTGDVLAMD 540
REGFLYFRDR LGDTFRWKGE NVSTHEVEGV LSQVDFLQQV NVYGVCVPGC EGKVGMAAVQ 600
LAPGQTFDGE KLYQHVRAWL PAYATPHFIR IQDAMEVTST FKLMKTRLVR EGFNVGIVVD 660
PLFVLDNRAQ SFRPLTAEMY QAVCEGTWRL 690 |
Gene Ontology | GO:0009925; C:basal plasma membrane; IEA:Compara. GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:UniProtKB. GO:0043234; C:protein complex; IEA:Compara. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0047747; F:cholate-CoA ligase activity; IEA:EC. GO:0015245; F:fatty acid transporter activity; IEA:Compara. GO:0031957; F:very long-chain fatty acid-CoA ligase activity; IDA:UniProtKB. GO:0015721; P:bile acid and bile salt transport; TAS:Reactome. GO:0006699; P:bile acid biosynthetic process; IDA:UniProtKB. GO:0046951; P:ketone body biosynthetic process; IEA:Compara. GO:0015911; P:plasma membrane long-chain fatty acid transport; IEA:Compara. GO:0006642; P:triglyceride mobilization; IEA:Compara. GO:0000038; P:very long-chain fatty acid metabolic process; IDA:UniProtKB. |
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