| Tag | Content |
|---|
| CPLM ID | CPLM-014923 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ral GTPase-activating protein subunit alpha-1 |
Protein Synonyms/Alias | GAP-related-interacting partner to E12; GRIPE; GTPase-activating RapGAP domain-like 1; Tuberin-like protein 1; p240 |
Gene Name | Ralgapa1 |
Gene Synonyms/Alias | Garnl1; Kiaa0884; Tulip1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 114 | SIGLILKKLLHTGNS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB (By similarity). May interact with the HLH region of TCF3/isoform E12. |
Sequence Annotation | DOMAIN 1795 2003 Rap-GAP.
REGION 1326 2035 Minimal domain that binds to TCF3/E12.
MOD_RES 753 753 Phosphothreonine (By similarity).
MOD_RES 772 772 Phosphoserine (By similarity).
MOD_RES 777 777 Phosphothreonine (By similarity).
MOD_RES 796 796 Phosphoserine (By similarity).
MOD_RES 859 859 Phosphoserine.
MOD_RES 860 860 Phosphoserine.
MOD_RES 863 863 Phosphoserine (By similarity).
MOD_RES 999 999 Phosphoserine.
MOD_RES 1001 1001 Phosphothreonine. |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; GTPase activation; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2035 AA |
Protein Sequence | MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH FSHIYYVFFE 60
NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH QRWQFHSIGL ILKKLLHTGN 120
SLKIRREGVR LFLLWLQALQ DNCSKEQLWM FSCLIPGFSA PQSEYGPRTL DNLINPPLSL 180
QETQVTIEEV TPLVPPQSGD KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL 240
FSHFKKFYLP YIFPNICKEN SLYHPVLDIP QIRPKPHYVM IKKDAETNET IYCTKEPFIQ 300
ARVIVIRWLV SFWLEPKPHS GPNIPGMEGE VLPKNIQRAA ASLVSREESK NDTVDKVDKS 360
AEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV FSSKRSNVNF VTEIFRQAFL 420
LPICEAAAMR KVVKVYQEWI QQEEKPLFMQ EPEDTAITCS DIPCSETVAD HDSAIEDGEK 480
REEENGTSTS EHVRNSSWTK NGSYQEAFHV CEEATEQNIQ AGTQAVLQVF IINSSNIFLL 540
EPANEIKNLL DEHTDMCKRI LNIYRYMVVQ VSMDKKTWEQ MLLVLLRVTE SVLKMSSQAF 600
LQFQGKKSMT LAGRLAGPLF QTLIVAWIKA NLNVYISREL WDDLLSVLSS LTYWEELATE 660
WSLTMETLTK VLARNLYSLD LSDLPLDKLS EQKQKKHKGK GVGHEFQKVS VDKSFSRGWS 720
RDQPGQAPMR QRSATTTGSP GTEKARSIVR QKTVDIDDAQ ILPRSTRVRH FSQSEDTGNE 780
VFGALHEEQP LPRSSSTSDI LEPFTVERAK VNKEDTSPKL PPLNSETGGN SANVPDLMDE 840
FIAERLRSGN ASTMTRRGSS PGSLEIPKDL PDILNKQNQM RPVDDPGVPS EWTSPASAGS 900
SDLMSSDSHS DSFSAFQCEG RKFDNFGFGT DIGIPSSADV DLGSGHHQST EEQEVASLTT 960
LHLDSETSSL NQQAFSAEVA TVTGSESASP VHSALGSRSQ TPSPSTLSRA HIEQKDLQLD 1020
EKLHHSVLQT PDDLEISEFP SECCSVMAGG TLTGWHADVA TVMWRRMLGI LGDVNAIMDP 1080
EIHAQVFDYL CELWQNLAKI RDNLGISADN LTSPSPPVLI PPLRILTPWL FKATMLTDKY 1140
KQGKLHAYKL ICNTMKRRQD VSPNRDFLTH FYNIMHCGLL HIDQDIVNTI IKHCSPQFFS 1200
LGLPGATMLI MDFIIAAGRV ASSAFLNAPR VEAQVLLGSL VCFPNLYCEL PALHPNIPDI 1260
AVSQFTDVKE LIIKTVLSSA RDEPSGPARC VALCSLGIWI CEELVHESHH PQIKEALNVI 1320
CVSLKFTNKT VAHVACNMLH MLVHYVPRLQ IHQPQSPLKI IQILIATITH LLPSTEASSY 1380
EMDKRLVVSL LLCLLDWIMA LPLKTLLQPV HATGAENDKT EKSVLNCIYK VLHGCVYGAQ 1440
SFSNPKYFPI SLSDLASVDY DPFMHLESLK EPEPLHSPDS ERSSKLQPVT EVKTQMQQGL 1500
ISIAARTVIT HLVNHLGHYP MSGGPAMLTS QVCENHDNHY SESTELSPEL FESPNIQFFV 1560
LNNTTLVSCI QIRSEESMPG GGLAAGLVSA NSNVRIIVRD LSGKYSWDSA ILYGPPIVSG 1620
LPEPTSFILS MSDQEKPEEP PTSNECLEDI AVKDGLSLQL RRFRETVPTW STIREEEDVL 1680
DELLQYLGTT SPECLQRTGI SLNVPAPQPL CISEKQENDV INAILKQYTE EKEFVEKHFN 1740
DLNMKASEQD EPTPQKPQSA FYYCRLLLSI LGMNSWDKRR SFHLLKKNEK LLRELRNLDS 1800
RQCRETHKIA VFYVAEGQED KYSILTNIGG SQAYEDFVAG LGWEVNLTNH CGFMGGLQKN 1860
RSTGLTTPYF ATSTVEVIFH VSTRMPSDSD DSLTKKLRHL GNDEVHIVWS EHTRDYRRGI 1920
IPTEFGDVLI VIYPMKNHMF SIQIMKKPEV PFFGPLFDGA IVNGKVLPIM VRSTAINASR 1980
ALKSLIPLYQ NFYEERARYL QTIVQHHLEP TTFEDFAAQV FSPAPYHHFP ADADH 2035 |
Gene Ontology | GO:0005829; C:cytosol; IBA:RefGenome. GO:0005739; C:mitochondrion; IEA:Compara. GO:0005634; C:nucleus; IDA:MGI. GO:0017123; F:Ral GTPase activator activity; ISS:UniProtKB. GO:0032859; P:activation of Ral GTPase activity; ISS:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |