CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013610
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein IMPACT 
Protein Synonyms/Alias
 Imprinted and ancient gene protein homolog 
Gene Name
 Impact 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
227YRIYCEDKQTFLQDSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity). 
Sequence Annotation
 DOMAIN 14 116 RWD.  
Keyword
 Complete proteome; Reference proteome; Translation regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 317 AA 
Protein Sequence
MAEVESGSNQ RQNEEIEAMA AIYGEEWCVI DEVAKIFCIR ITDDMDDPKW TLCLQVMLPS 60
EYPGTAPPVY QLNAPWLKGQ ERAELAKSLE EIYMKNIGES ILYQWVEKIR DALIQKSQIT 120
EPGPDEKKKT EEEEVEGEDD PILEHPPENP VKTWDLKISE SAPEAEELPP IAHGAPITDR 180
RSTFQAHLAP VVCIDQVKKV LAKLYENKKI ASATHNIYAY RIYCEDKQTF LQDSEDDGET 240
AAGGRLLHLM EILNVKNVMV VVSRWYGGIL LGPDRFKHIN NCARNILVEK NFTNSPEESA 300
KSFGKKKVKK DKKKGDH 317 
Gene Ontology
 GO:0001933; P:negative regulation of protein phosphorylation; IEA:Compara.
 GO:0006446; P:regulation of translational initiation; IEA:Compara. 
Interpro
 IPR023582; Impact.
 IPR001498; Impact_N.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR006575; RWD-domain.
 IPR016135; UBQ-conjugating_enzyme/RWD.
 IPR020569; UPF0029_Impact_CS. 
Pfam
 PF05773; RWD
 PF01205; UPF0029 
SMART
 SM00591; RWD 
PROSITE
 PS50908; RWD
 PS00910; UPF0029 
PRINTS