CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018835
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Proprotein convertase subtilisin/kexin type 5 
Protein Synonyms/Alias
 Proprotein convertase 5; PC5; Proprotein convertase 6; PC6; hPC6; Subtilisin/kexin-like protease PC5 
Gene Name
 PCSK5 
Gene Synonyms/Alias
 PC5; PC6 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
56EANRIASKYGFINIGubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins. 
Sequence Annotation
 DOMAIN 462 600 Homo B/P.
 DOMAIN 869 913 PLAC.
 REGION 115 454 Catalytic.
 REGION 636 1727 CRM (Cys-rich motif).
 REGION 1807 1826 AC 1 (By similarity).
 REGION 1838 1860 AC 2 (By similarity).
 MOTIF 519 521 Cell attachment site (Potential).
 ACT_SITE 171 171 Charge relay system (By similarity).
 ACT_SITE 212 212 Charge relay system (By similarity).
 ACT_SITE 386 386 Charge relay system (By similarity).
 CARBOHYD 225 225 N-linked (GlcNAc...) (Potential).
 CARBOHYD 381 381 N-linked (GlcNAc...) (Potential).
 CARBOHYD 665 665 N-linked (GlcNAc...) (Potential).
 CARBOHYD 752 752 N-linked (GlcNAc...) (Potential).
 CARBOHYD 802 802 N-linked (GlcNAc...) (Potential).
 CARBOHYD 852 852 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1014 1014 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1191 1191 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1290 1290 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1497 1497 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1685 1685 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1707 1707 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Cleavage on pair of basic residues; Complete proteome; Glycoprotein; Hydrolase; Membrane; Pregnancy; Protease; Reference proteome; Repeat; Secreted; Serine protease; Signal; Transmembrane; Transmembrane helix; Zymogen. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1860 AA 
Protein Sequence
MGWGSRCCCP GRLDLLCVLA LLGGCLLPVC RTRVYTNHWA VKIAGGFPEA NRIASKYGFI 60
NIGQIGALKD YYHFYHSRTI KRSVISSRGT HSFISMEPKV EWIQQQVVKK RTKRDYDFSR 120
AQSTYFNDPK WPSMWYMHCS DNTHPCQSDM NIEGAWKRGY TGKNIVVTIL DDGIERTHPD 180
LMQNYDALAS CDVNGNDLDP MPRYDASNEN KHGTRCAGEV AAAANNSHCT VGIAFNAKIG 240
GVRMLDGDVT DMVEAKSVSF NPQHVHIYSA SWGPDDDGKT VDGPAPLTRQ AFENGVRMGR 300
RGLGSVFVWA SGNGGRSKDH CSCDGYTNSI YTISISSTAE SGKKPWYLEE CSSTLATTYS 360
SGESYDKKII TTDLRQRCTD NHTGTSASAP MAAGIIALAL EANPFLTWRD VQHVIVRTSR 420
AGHLNANDWK TNAAGFKVSH LYGFGLMDAE AMVMEAEKWT TVPRQHVCVE STDRQIKTIR 480
PNSAVRSIYK ASGCSDNPNR HVNYLEHVVV RITITHPRRG DLAIYLTSPS GTRSQLLANR 540
LFDHSMEGFK NWEFMTIHCW GERAAGDWVL EVYDTPSQLR NFKTPGKLKE WSLVLYGTSV 600
QPYSPTNEFP KVERFRYSRV EDPTDDYGTE DYAGPCDPEC SEVGCDGPGP DHCNDCLHYY 660
YKLKNNTRIC VSSCPPGHYH ADKKRCRKCA PNCESCFGSH GDQCMSCKYG YFLNEETNSC 720
VTHCPDGSYQ DTKKNLCRKC SENCKTCTEF HNCTECRDGL SLQGSRCSVS CEDGRYFNGQ 780
DCQPCHRFCA TCAGAGADGC INCTEGYFME DGRCVQSCSI SYYFDHSSEN GYKSCKKCDI 840
SCLTCNGPGF KNCTSCPSGY LLDLGMCQMG AICKDGEYVD EHGHCQTCEA SCAKCQGPTQ 900
EDCTTCPMTR IFDDGRCVSN CPSWKFEFEN QCHPCHHTCQ RCQGSGPTHC TSCGADNYGR 960
EHFLYQGECG DSCPEGHYAT EGNTCLPCPD NCELCHSVHV CTRCMKGYFI APTNHTCQKL 1020
ECGQGEVQDP DYEECVPCEE GCLGCSLDDP GTCTSCAMGY YRFDHHCYKT CPEKTYSEEV 1080
ECKACDSNCG SCDQNGCYWC EEGFFLLGGS CVRKCGPGFY GDQEMGECES CHRACETCTG 1140
PGHDECSSCQ EGLQLLRGMC VHATKTQEEG KFWNDILRKL QPCHSSCKTC NGSATLCTSC 1200
PKGAYLLAQA CVSSCPQGTW PSVRSGSCEN CTEACAICSG ADLCKKCQMQ PGHPLFLHEG 1260
RCYSKCPEGS YAEDGICERC SSPCRTCEGN ATNCHSCEGG HVLHHGVCQE NCPERHVAVK 1320
GVCKHCPEMC QDCIHEKTCK ECTPEFFLHD DMCHQSCPRG FYADSRHCVP CHKDCLECSG 1380
PKADDCELCL ESSWVLYDGL CLEECPAGTY YEKETKECRD CHKSCLTCSS SGTCTTCQKG 1440
LIMNPRGSCM ANEKCSPSEY WDEDAPGCKP CHVKCFHCMG PAEDQCQTCP MNSLLLNTTC 1500
VKDCPEGYYA DEDSNRCAHC HSSCRTCEGR HSRQCHSCRP GWFQLGKECL LQCREGYYAD 1560
NSTGRCERCN RSCKGCQGPR PTDCLSCDRF FFLLRSKGEC HRSCPDHYYV EQSTQTCERC 1620
HPTCDQCKGK GALNCLSCVW SYHLMGGICT SDCLVGEYRV GEGEKFNCEK CHESCMECKG 1680
PGAKNCTLCP ANLVLHMDDS HCLHCCNTSD PPSAQECCDC QDTTDECILR TSKVRPATEH 1740
FKTALFITSS MMLVLLLGAA VVVWKKSRGR VQPAAKAGYE KLADPNKSYS SYKSSYREST 1800
SFEEDQVIEY RDRDYDEDDD DDIVYMGQDG TVYRKFKYGL LDDDDIDELE YDDESYSYYQ 1860 
Gene Ontology
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0005615; C:extracellular space; ISS:BHF-UCL.
 GO:0005796; C:Golgi lumen; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030141; C:secretory granule; ISS:BHF-UCL.
 GO:0042277; F:peptide binding; ISS:BHF-UCL.
 GO:0004252; F:serine-type endopeptidase activity; IDA:BHF-UCL.
 GO:0009952; P:anterior/posterior pattern specification; IMP:BHF-UCL.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0042089; P:cytokine biosynthetic process; ISS:BHF-UCL.
 GO:0007566; P:embryo implantation; ISS:BHF-UCL.
 GO:0048566; P:embryonic digestive tract development; IMP:BHF-UCL.
 GO:0048706; P:embryonic skeletal system development; IMP:BHF-UCL.
 GO:0007507; P:heart development; ISS:BHF-UCL.
 GO:0001822; P:kidney development; IMP:BHF-UCL.
 GO:0035108; P:limb morphogenesis; ISS:BHF-UCL.
 GO:0032455; P:nerve growth factor processing; TAS:Reactome.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0043043; P:peptide biosynthetic process; IDA:BHF-UCL.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0002001; P:renin secretion into blood stream; IEP:BHF-UCL.
 GO:0030323; P:respiratory tube development; ISS:BHF-UCL.
 GO:0006465; P:signal peptide processing; IDA:HGNC.
 GO:0019067; P:viral assembly, maturation, egress, and release; IEP:BHF-UCL. 
Interpro
 IPR000742; EG-like_dom.
 IPR006212; Furin_repeat.
 IPR008979; Galactose-bd-like.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR000209; Peptidase_S8/S53_dom.
 IPR023827; Peptidase_S8_Asp-AS.
 IPR022398; Peptidase_S8_His-AS.
 IPR023828; Peptidase_S8_Ser-AS.
 IPR015500; Peptidase_S8_subtilisin-rel.
 IPR009020; Prot_inh_propept.
 IPR002884; PrprotnconvertsP. 
Pfam
 PF01483; P_proprotein
 PF00082; Peptidase_S8 
SMART
 SM00181; EGF
 SM00261; FU 
PROSITE
 PS50900; PLAC
 PS00136; SUBTILASE_ASP
 PS00137; SUBTILASE_HIS
 PS00138; SUBTILASE_SER 
PRINTS
 PR00723; SUBTILISIN.