UniProt Accession

 CD180_HUMAN; Q99467; B2R7Z7; Q32MM5 

Genbank Protein ID

 D83597; AK313177; AC026445; CH471137; BC109069; BC109070 

Genbank Nucleotide ID

 BAA12019.1; BAG35994.1; EAW51318.1; AAI09070.1; AAI09071.1 

Protein Name

 CD180 antigen 

Protein Synonyms/Alias

 Lymphocyte antigen 64; Radioprotective 105 kDa protein; CD180 

Gene Name

 CD180 

Gene Synonyms/Alias

 LY64; RP105 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
176	DFPARNLKVLDFQNN	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity). 

Sequence Annotation

 DOMAIN 33 53 LRRNT.
 REPEAT 54 75 LRR 1.
 REPEAT 78 99 LRR 2.
 REPEAT 102 123 LRR 3.
 REPEAT 126 147 LRR 4.
 REPEAT 150 171 LRR 5.
 REPEAT 174 195 LRR 6.
 REPEAT 201 221 LRR 7.
 REPEAT 275 296 LRR 8.
 REPEAT 299 320 LRR 9.
 REPEAT 322 343 LRR 10.
 REPEAT 346 366 LRR 11.
 REPEAT 371 391 LRR 12.
 REPEAT 397 418 LRR 13.
 REPEAT 421 442 LRR 14.
 REPEAT 446 466 LRR 15.
 REPEAT 470 493 LRR 16.
 REPEAT 497 518 LRR 17.
 REPEAT 521 544 LRR 18.
 REPEAT 546 564 LRR 19.
 DOMAIN 577 627 LRRCT.
 CARBOHYD 34 34 N-linked (GlcNAc...) (Potential).
 CARBOHYD 53 53 N-linked (GlcNAc...) (Potential).
 CARBOHYD 70 70 N-linked (GlcNAc...) (Potential).
 CARBOHYD 78 78 N-linked (GlcNAc...).
 CARBOHYD 201 201 N-linked (GlcNAc...) (Potential).
 CARBOHYD 234 234 N-linked (GlcNAc...) (Potential).
 CARBOHYD 244 244 N-linked (GlcNAc...) (Potential).
 CARBOHYD 394 394 N-linked (GlcNAc...) (Potential).
 CARBOHYD 402 402 N-linked (GlcNAc...).
 CARBOHYD 451 451 N-linked (GlcNAc...).
 CARBOHYD 573 573 N-linked (GlcNAc...) (Potential).  

Keyword

 3D-structure; Cell membrane; Complete proteome; Direct protein sequencing; Glycoprotein; Immunity; Inflammatory response; Innate immunity; Leucine-rich repeat; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 661 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO:0031666; P:positive regulation of lipopolysaccharide-mediated signaling pathway; IGI:MGI. 

Interpro

 IPR000483; Cys-rich_flank_reg_C.
 IPR001611; Leu-rich_rpt. 

Pfam

  

SMART

 SM00082; LRRCT 

PROSITE

 PS51450; LRR 

PRINTS