CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028631
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine--tRNA ligase, cytoplasmic 
Protein Synonyms/Alias
  
Gene Name
 Sars 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
12LDLFRVDKGGDPALIacetylation[1]
218DDNSYDEKYLIATSEacetylation[2]
218DDNSYDEKYLIATSEubiquitination[3]
245RPEDLPIKYAGLSTCubiquitination[3]
275FRVHQFEKIEQFVYSacetylation[2]
275FRVHQFEKIEQFVYSubiquitination[3]
328LNHAASKKLDLEAWFubiquitination[3]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 352 AA 
Protein Sequence
MVLDLDLFRV DKGGDPALIR ETQEKRFKDP GLVDQLVKAD SEWRRCRFRA DNLNKLKNLC 60
SKTIGEKMKK KEAVGDDESV PENVLNFDDL TADALAALKV SQIKKVRLLI DEAIQKCDGE 120
RVKLEAERFE NLREIGNLLH PSVPISNDEG PLVFLEQALI QYALRTLGSR GYTPIYTPFF 180
MRKEVMQEVA QLSQFDEELY KVIGKGSEKS DDNSYDEKYL IATSEQPIAA LHRDEWLRPE 240
DLPIKYAGLS TCFRQEVGSH GRDTRGIFRV HQFEKIEQFV YSSPHDNKSW EMFDEMIATA 300
EEFYQSLGIP YHIVNIVSGS LNHAASKKLD LEAWFPGSGA FRELVSCSNC TD 352 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004828; F:serine-tRNA ligase activity; IEA:InterPro.
 GO:0006434; P:seryl-tRNA aminoacylation; IEA:InterPro. 
Interpro
 IPR002314; aa-tRNA-synt_IIb_cons-dom.
 IPR006195; aa-tRNA-synth_II.
 IPR002317; Ser-tRNA-ligase_type_1.
 IPR015866; Ser-tRNA-synth_1_N.
 IPR010978; tRNA-bd_arm. 
Pfam
 PF02403; Seryl_tRNA_N
 PF00587; tRNA-synt_2b 
SMART
  
PROSITE
 PS50862; AA_TRNA_LIGASE_II 
PRINTS
 PR00981; TRNASYNTHSER.