CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019530
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 317 
Protein Synonyms/Alias
  
Gene Name
 ZNF317 
Gene Synonyms/Alias
 KIAA1588 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
248RRIHTGEKPYECSDCubiquitination[1]
350FQHPSHLKEHVRNHTubiquitination[1]
397YECKECGKSFGDLVSubiquitination[2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation. 
Sequence Annotation
 DOMAIN 57 128 KRAB.
 ZN_FING 222 244 C2H2-type 1.
 ZN_FING 250 272 C2H2-type 2.
 ZN_FING 278 300 C2H2-type 3.
 ZN_FING 306 328 C2H2-type 4.
 ZN_FING 334 356 C2H2-type 5.
 ZN_FING 362 384 C2H2-type 6.
 ZN_FING 390 412 C2H2-type 7.
 ZN_FING 418 440 C2H2-type 8.
 ZN_FING 446 468 C2H2-type 9.
 ZN_FING 474 496 C2H2-type 10.
 ZN_FING 502 524 C2H2-type 11.
 ZN_FING 530 552 C2H2-type 12.
 ZN_FING 558 580 C2H2-type 13.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 595 AA 
Protein Sequence
MAALSPTFAT STQDSTCLQD SEFPVSSKDH SCPQNLDLFV CSGLEPHTPS VGSQESVTFQ 60
DVAVDFTEKE WPLLDSSQRK LYKDVMLENY SNLTSLGYQV GKPSLISHLE QEEEPRTEER 120
GAHQGACADW ETPSKTKWSL LMEDIFGKET PSGVTMERAG LGEKSTEYAH LFEVFGMDPH 180
LTQPMGRHAG KRPYHRRDYG VAFKGRPHLT QHMSMYDGRK MHECHQCQKA FTTSASLTRH 240
RRIHTGEKPY ECSDCGKAFN DPSALRSHAR THLKEKPFDC SQCGNAFRTL SALKIHMRVH 300
TGERPYKCDQ CGKAYGRSCH LIAHKRTHTG ERPYECHDCG KAFQHPSHLK EHVRNHTGEK 360
PYACTQCGKA FRWKSNFNLH KKNHMVEKTY ECKECGKSFG DLVSRRKHMR IHIVKKPVEC 420
RQCGKTFRNQ SILKTHMNSH TGEKPYGCDL CGKAFSASSN LTAHRKIHTQ ERRYECAACG 480
KVFGDYLSRR RHMSVHLVKK RVECRQCGKA FRNQSTLKTH MRSHTGEKPY ECDHCGKAFS 540
IGSNLNVHRR IHTGEKPYEC LVCGKAFSDH SSLRSHVKTH RGEKLFVSSV WKRLQ 595 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS