UniProt Accession

 H2B1_SCHPO; P04913 

Genbank Protein ID

 M11494; X05220; CU329672 

Genbank Nucleotide ID

 AAA35312.1; CAA28847.1; CAA21865.1 

Protein Name

 Histone H2B-alpha 

Protein Synonyms/Alias

 H2B.1 

Gene Name

 htb1 

Gene Synonyms/Alias

 SPCC622.09 

Created Date

 July 27, 2013 

Organism

 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 

NCBI Taxa ID

 284812 

Lysine Modification

Position	Peptide	Type	References
6	**MSAAEKKPASKAP	acetylation	[1]
11	AEKKPASKAPAGKAP	acetylation	[1]
16	ASKAPAGKAPRDTMK	acetylation	[1]

Reference

 [1] Mapping Post-translational Modifications of Histones H2A, H2B and H4 in Schizosaccharomyces pombe.
 Xiong L, Wang Y.
 Int J Mass Spectrom. 2011 Mar 30;301(1-3):159-165. [PMID: 21516229] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 6 6 N6-acetyllysine; alternate (By
 MOD_RES 7 7 N6-acetyllysine; alternate (By
 MOD_RES 10 10 Phosphoserine (By similarity).
 MOD_RES 11 11 N6-acetyllysine (By similarity).
 CROSSLNK 6 6 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 7 7 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 120 120 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Chromosome; Complete proteome; Direct protein sequencing; DNA-binding; Isopeptide bond; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 126 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IDA:PomBase.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR000558; Histone_H2B. 

Pfam

 PF00125; Histone 

SMART

 SM00427; H2B 

PROSITE

 PS00357; HISTONE_H2B 

PRINTS

 PR00621; HISTONEH2B.