| Tag | Content |
|---|
| CPLM ID | CPLM-001742 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
Protein Synonyms/Alias | HMG-CoA reductase |
Gene Name | HMGCR |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) |
NCBI Taxa ID | 10029 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 142 | SRASALAKFALSSNS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins (By similarity). |
Sequence Annotation | DOMAIN 61 218 SSD.
REGION 340 449 Linker.
REGION 450 887 Catalytic.
MOTIF 75 78 INSIG-binding motif (By similarity).
ACT_SITE 558 558 Charge relay system (By similarity).
ACT_SITE 690 690 Charge relay system (By similarity).
ACT_SITE 766 766 Charge relay system (By similarity).
ACT_SITE 865 865 Proton donor (By similarity).
MOD_RES 871 871 Phosphoserine; by AMPK (By similarity).
CARBOHYD 281 281 N-linked (GlcNAc...) (Potential).
CARBOHYD 517 517 N-linked (GlcNAc...) (Potential).
CARBOHYD 869 869 N-linked (GlcNAc...) (Potential).
CROSSLNK 89 89 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 248 248 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Cholesterol biosynthesis; Cholesterol metabolism; Endoplasmic reticulum; Glycoprotein; Isopeptide bond; Lipid biosynthesis; Lipid metabolism; Membrane; NADP; Oxidoreductase; Phosphoprotein; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transmembrane; Transmembrane helix; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 887 AA |
Protein Sequence | MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC PKFEEDVLSS 60
DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI FSSFVFSTVV IHFLDKELTG 120
LNEALPFFLL LIDLSRASAL AKFALSSNSQ DEVRENIARG MAILGPTFTL DALVECLVIG 180
VGTMSGVRQL EIMCCFGCMS VLANYFVFMT FFPACVSLVL ELSRESREGR PIWQLSHFAR 240
VLEEEENKPN PVTQRVKMIM SLGLVLVHAH SRWIADPSPQ NSTTEHSKVS LGLDEDVSKR 300
IEPSVSLWQF YLSKMISMDI EQVVTLSLAF LLAVKYIFFE QAETESTLSL KNPITSPVVT 360
PKKAPDNCCR REPLLVRRSE KLSSVEEEPG VSQDRKVEVI KPLVVETESA SRATFVLGAS 420
GTSPPVAART QELEIELPSE PRPNEECLQI LESAEKGAKF LSDAEIIQLV NAKHIPAYKL 480
ETLMETHERG VSIRRQLLST KLPEPSSLQY LPYRDYNYSL VMGACCENVI GYMPIPVGVA 540
GPLCLDGKEY QVPMATTEGC LVASTNRGCR AIGLGGGASS RVLADGMTRG PVVRLPRACD 600
SAEVKAWLET PEGFAVIKDA FDSTSRFARL QKLHVTMAGR NLYIRFQSKT GDAMGMNMIS 660
KGTEKALLKL QEFFPEMQIL AVSGNYCTDK KPAAINWIEG RGKTVVCEAV IPAKVVREVL 720
KTTTEAMIDV NINKNLVGSA MAGSIGGYNA HAANIVTAIY IACGQDAAQN VGSSNCITLM 780
EASGPTNEDL YISCTMPSIE IGTVGGGTNL LPQQACLQML GVQGACKDNP GENARQLARI 840
VCGTVMAGEL SLMAALAAGH LVRSHMVHNR SKINLQDLQG TCTKKSA 887 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; TAS:UniProtKB. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC. GO:0042282; F:hydroxymethylglutaryl-CoA reductase activity; IDA:UniProtKB. GO:0050661; F:NADP binding; IEA:InterPro. GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW. GO:0015936; P:coenzyme A metabolic process; IEA:InterPro. GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |