UniProt Accession

 RPOE_ECOLI; P0AGB6; P34086; Q2MAF7 

Genbank Protein ID

 D13169; U37089; D64044; U00096; AP009048; U10148 

Genbank Nucleotide ID

 AAC45314.1; BAA10920.1; AAC75626.1; BAE76749.1; AAA83998.1 

Protein Name

 RNA polymerase sigma-E factor 

Protein Synonyms/Alias

 Sigma-24 

Gene Name

 rpoE 

Gene Synonyms/Alias

 sigE; b2573; JW2557 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
16	VLVERVQKGDQKAFN	acetylation	[1]
20	RVQKGDQKAFNLLVV	acetylation	[1]
56	VVQEAFIKAYRALDS	acetylation	[1]
83	RIAVNTAKNYLVAQG	acetylation	[1]
184	AREAIDNKVQPLIRR	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in heat shock and oxidative stress response; it is believed to control protein processing in the extracytoplasmic compartment. 

Sequence Annotation

 DNA_BIND 156 175 H-T-H motif (By similarity).
 MOTIF 48 61 Polymerase core binding.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; DNA-binding; Reference proteome; Sigma factor; Stress response; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 191 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:EcoCyc.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
 GO:0006352; P:DNA-dependent transcription, initiation; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IDA:EcoCyc.
 GO:0006970; P:response to osmotic stress; IDA:EcoCyc.
 GO:0009266; P:response to temperature stimulus; IDA:EcoCyc. 

Interpro

 IPR014284; RNA_pol_sigma-70_dom.
 IPR000838; RNA_pol_sigma70_ECF_CS.
 IPR007627; RNA_pol_sigma70_r2.
 IPR013249; RNA_pol_sigma70_r4_t2.
 IPR014286; RNA_pol_sigma70_RpoE.
 IPR013325; RNA_pol_sigma_r2.
 IPR013324; RNA_pol_sigma_r3_r4.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF04542; Sigma70_r2
 PF08281; Sigma70_r4_2 

SMART

  

PROSITE

 PS01063; SIGMA70_ECF 

PRINTS