CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017677
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Exophilin-5 
Protein Synonyms/Alias
 Synaptotagmin-like protein homolog lacking C2 domains b; SlaC2-b; Slp homolog lacking C2 domains b 
Gene Name
 EXPH5 
Gene Synonyms/Alias
 KIAA0624; SLAC2B 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
660LQKIFPNKPASHPMRubiquitination[1]
973PFRNERGKGKIRHHIacetylation[2]
988SCIEKLSKTESISVPubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May act as Rab effector protein and play a role in vesicle trafficking. 
Sequence Annotation
 DOMAIN 7 63 RabBD.
 MOD_RES 341 341 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Epidermolysis bullosa; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1989 AA 
Protein Sequence
MTKVPPAFDF SFLNDEEARK ILQVLERNEE LQRAEKDRIS KLQKTKRDIR WLQGVTGEWF 60
EEIQRKKFCN ETDVSQMLKQ PLTYRLSKEM AKNDPIELPT SRSKNVTNQK KPTPFSSRMS 120
FRSSFASLFS FRKSGKETSK LPSLGQKGCD GHAGPPMPVR GAAVQAKIYN SPLENHLVDS 180
TFVPKPAVMR EESGMPPPWD ASLLENEFFQ VLDDLDSKLA QEQSASSVNT RTPLNYGSRT 240
QFGHFYSSGN RHGNITERHK KHYNETSNMS IYDILRPGTP REGFKTFSPR TSTIYDMYRT 300
REPRVFKEDY VQKNTFGSTS LCFDSRQRSA LPATGHFTAR SLHFPATTQS KSGFIPPRHQ 360
QSPKRTPLSS IIWNRSDSSR DRENQEEFLR APSPMEIDPA DKYVYPRGFQ ENKRYESYHS 420
QNVYQRVSLN APMENAMSPD TFENSENMPF YHQSNTFTRS FFSNTFGRSG EQRRFGQGPF 480
WGQEKGHSFW SDFHRSRKSF SSSDRDFEMI SMEANSVSAI HGHNVSSEHW ESFSSGYGTD 540
VSRGQEEPHP WQFDFQRSTL DSMVVSHGNE TQLTPHFGTP NVCSMTGSSY HVKSSELVSQ 600
QDSSPVEVHI NKEASSFGIA QTLASSFKTS FSQISDDRRN PQSPNLQNPT VTLQKIFPNK 660
PASHPMRSHT EVTVTSSNSV DSLPLAKSQP NILVTEVNNE KDLNESISEE DKQLSKMDQT 720
NKAGEIPQPV SQTGISNSLP DFQNPLSQDS AKSNGFGFNA STIISSKKSP RVFSRKDTSK 780
MYIPHTDKSN DIKQDKRFTE NRKLGSTASL PFIQEHRTPP SFPRTDQGCH QELTVNNEDI 840
SRIITNNHWS SALTDTQNAQ YSKCKLTPGH KTSCDSLDLS SAALPDSSPS KNSSLDAPVV 900
PSTTVFSRRS PSDKDPSLGE REEKDNAGKN QKNQFIVSHS ENQERNDSPV PTHDEVVDVK 960
CHSHSPFRNE RGKGKIRHHI SCIEKLSKTE SISVPTSDHR SLIEANQSNS KVSELDTIYC 1020
TLPRKSSSFL IHGRQSGSKI MAASLRNGPP PFQIKNNVED AMGNYMLNKF SPSSPESANE 1080
CSKVLSDSAL EAPEATERMT NVKSSGSTSV RKGPLPFLIN RAMSCPSGEP HASTGREGRK 1140
KPLTSGMDAS ELTPRAWERI ISPVESDSSV RDCSLTKRQH QKENFQEYTE KEGKMAASRR 1200
SVFALSNEDP LPFCSDLSGK ERGKTLHKVK TTSTFSVSGD EDNVKCLEVV SIYYTLPRKP 1260
SKKFCNLLQQ YTQNTNLLIE SPQVETETFP NALEKDKQNY STREQSGTPS CENLKMSVNS 1320
DQTLTTENMT AFRLSNRGPL APTLQEMASV EAAVSLPEEE SKAREIFSDN LAKTPLGDSE 1380
NKKERGKKLQ SETLHTSLML QRKNVSEEKS ENCQQSINSS NSGPSSLPAL SEVNIGNSQT 1440
RRSSWECTGS GRAIPFTGSG KCPQKDHTST AVGDGSSGSQ PREGRGDIGT NCQKMTNKTL 1500
SHSESQVFAL TPALHKLQLG EETQSDEPNL ESLQSEPREL PQRSQEANMT ESRKAEDEMQ 1560
KSAWDQPSLP EGNKNKTNLD DLVKGENRSS VKHRLAAMSK ASRKFPAKDV SPRRHVATIF 1620
PQSGSRSGFD HLSLGTVECN PLFPEPTPKS AESIGESRLS ENGKHVKKSE NLLPITVLPN 1680
REPSTHVSNQ KSNSISQRHQ NEFKNVSESP SKHENSKDVT AAQNLVRESG APSPITFTSL 1740
REAEFSDNQR RLSPPFPLEP AQKSRVSSPL ASFLQQQRSA SSLEWEPEPH LYRSKSLKSI 1800
NVHGDLLRKS HPPKVRERHF SESTSIDNAL SRLTLGNEFS VNNGYSRRFR SFSELPSCDG 1860
NESWAYRSGT KTGPRSAISI YRPIDYGIFG KEQQLAFLEN VKRSLTQGRL WKPSFLKNPG 1920
FLKDDLRNPP NPSESLSSNS PSSQVPEDGL SPSEPLNIYE DDPVDSNCDT DTTTDDEYYL 1980
DENDKESEL 1989 
Gene Ontology
 GO:0005768; C:endosome; IDA:UniProtKB.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0003334; P:keratinocyte development; IMP:UniProtKB.
 GO:0071985; P:multivesicular body sorting pathway; IMP:UniProtKB.
 GO:0045921; P:positive regulation of exocytosis; IMP:UniProtKB.
 GO:0050714; P:positive regulation of protein secretion; IMP:UniProtKB. 
Interpro
 IPR010911; Rab-bd_domain.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
  
SMART
  
PROSITE
 PS50916; RABBD 
PRINTS