CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040376
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Clathrin heavy chain 1 
Protein Synonyms/Alias
  
Gene Name
 Cltc 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
35SLAQRLEKHELIEFRacetylation[1, 2]
35SLAQRLEKHELIEFRubiquitination[3]
50RIAAYLFKGNNRWKQacetylation[1]
50RIAAYLFKGNNRWKQubiquitination[3]
69CKKDSLYKDAMQYASubiquitination[3]
143VMKEYLTKVDAIKEKubiquitination[3]
148LTKVDAIKEKVDKLDacetylation[4]
153AIKEKVDKLDASESLacetylation[5]
153AIKEKVDKLDASESLubiquitination[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 216 AA 
Protein Sequence
XNNLFITEED YQALRTSIDA YDNFDNISLA QRLEKHELIE FRRIAAYLFK GNNRWKQSVE 60
LCKKDSLYKD AMQYASESKD TELAEELLQW FLQEEKRECF GACLFTCYDL LRPDVVLETA 120
WRHNIMDFAM PYFIQVMKEY LTKVDAIKEK VDKLDASESL RKEEEQATET QPIVYGQPQL 180
MLTAGPSVAV PPQAPFGYGY TAPPYGQPQP GFGYSM 216 
Gene Ontology
 GO:0030117; C:membrane coat; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0031523; C:Myb complex; ISO:MGI.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0090307; P:spindle assembly involved in mitosis; ISO:MGI.
 GO:0016192; P:vesicle-mediated transport; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR000547; Clathrin_H-chain/VPS_repeat.
 IPR011990; TPR-like_helical. 
Pfam
 PF00637; Clathrin 
SMART
  
PROSITE
  
PRINTS