CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002312
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein SCP160 
Protein Synonyms/Alias
 Protein HX 
Gene Name
 SCP160 
Gene Synonyms/Alias
 HX; YJL080C; J1017 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
176ELVKKLTKPINAVIEacetylation[1]
254AKILAIVKEETKNATacetylation[1]
321TSIQDYLKKLASNLDacetylation[1]
322SIQDYLKKLASNLDEacetylation[1]
398VESLDISKAHSKNLTacetylation[1]
461SDEANDIKAVRKELIacetylation[1]
622KAAKAANKIFESILNacetylation[1]
722KELIVPVKFHGSLIGacetylation[1]
911PNADSENKDITVQGPacetylation[1]
911PNADSENKDITVQGPubiquitination[2]
920ITVQGPQKFVKKVVEacetylation[1]
931KVVEEINKIVKDAENacetylation[1]
934EEINKIVKDAENSVTubiquitination[2]
996GAPENVEKAEKKILNacetylation[1]
996GAPENVEKAEKKILNubiquitination[2]
1065PIEIPLEKVCGSTEGubiquitination[2]
1077TEGENAEKTKFTIEEubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Involved in the control of mitotic chromosome transmission. Required during cell division for faithful partitioning of the ER-nuclear envelope membranes which, in S.cerevisiae, enclose the duplicated chromosomes. 
Sequence Annotation
 DOMAIN 177 249 KH 1.
 DOMAIN 634 702 KH 2.
 DOMAIN 712 771 KH 3.
 DOMAIN 782 851 KH 4.
 DOMAIN 861 929 KH 5.
 DOMAIN 939 1001 KH 6.
 DOMAIN 1153 1216 KH 7.
 MOD_RES 50 50 Phosphothreonine.
 MOD_RES 54 54 Phosphoserine.
 MOD_RES 63 63 Phosphoserine.
 MOD_RES 87 87 Phosphoserine.
 MOD_RES 89 89 Phosphoserine.
 MOD_RES 630 630 Phosphoserine.
 MOD_RES 1112 1112 Phosphoserine.  
Keyword
 Complete proteome; Endoplasmic reticulum; Membrane; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1222 AA 
Protein Sequence
MSEEQTAIDS PPSTVEGSVE TVTTIDSPST TASTIAATAE EHPQLEKKPT PLPSLKDLPS 60
LGSNAAFANV KVSWGPNMKP AVSNSPSPSP SAPSLTTGLG AKRMRSKNIQ EAFTLDLQSQ 120
LSITKPELSR IVQSVKKNHD VSVESTLSKN ARTFLVSGVA ANVHEAKREL VKKLTKPINA 180
VIEVPSKCKA SIIGSGGRTI REISDAYEVK INVSKEVNEN SYDEDMDDTT SNVSLFGDFE 240
SVNLAKAKIL AIVKEETKNA TIKLVVEDEK YLPYIDVSEF ASDEGDEEVK VQFYKKSGDI 300
VILGPREKAK ATKTSIQDYL KKLASNLDEE KVKIPSKFQF LIDAEELKEK YNVIVTFPST 360
PDDELVSFVG LRDKVGEAIT YARSSSKSYV VESLDISKAH SKNLTHAKNL IMYFTKYSVL 420
KGLEESHPNV KISLPSIQSL PTAETVTIHI SAKSDEANDI KAVRKELISF VNNIPPSETL 480
VITDLDYELF GGSIKHCLLA SESSVAFVQF GDYYPNDNSI LLVALTEDED FKPSIEEIQA 540
SLNKANESLN SLRTKQNNME TKTYEFSEEV QDSLFKPSSA TWKLIMEDIS EQEGHLQIKL 600
HTPEENQLTV RGDEKAAKAA NKIFESILNS PSSKSKMTVN IPANSVARLI GNKGSNLQQI 660
REKFACQIDI PNEENNNASK DKTVEVTLTG LEYNLTHAKK YLAAEAKKWA DIITKELIVP 720
VKFHGSLIGP HGTYRNRLQE KYNVFINFPR DNEIVTIRGP SRGVNKAHEE LKALLDFEME 780
NGHKMVINVP AEHVPRIIGK NGDNINDIRA EYGVEMDFLQ KSTDPKAQET GEVELEITGS 840
RQNIKDAAKR VESIVAEASD FVTEVLKIDH KYHKSIVGSG GHILREIISK AGGEEIRNKS 900
VDIPNADSEN KDITVQGPQK FVKKVVEEIN KIVKDAENSV TKTIDIPAER KGALIGPGGI 960
VRRQLESEFN INLFVPNKDD PSGKITITGA PENVEKAEKK ILNEIIRENF DREVDVPASI 1020
YEYVSERGAF IQKLRMDLSV NVRFGNTSKK ANKLARAPIE IPLEKVCGST EGENAEKTKF 1080
TIEEVGAPTS SEEGDITMRL TYEPIDLSSI LSDGEEKEVT KDTSNDSAKK EEALDTAVKL 1140
IKERIAKAPS ATYAGYVWGA DTRRFNMIVG PGGSNIKKIR EAADVIINVP RKSDKVNDVV 1200
YIRGTKAGVE KAGEMVLKSL RR 1222 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0005844; C:polysome; IDA:SGD.
 GO:0003723; F:RNA binding; IDA:SGD.
 GO:0030466; P:chromatin silencing at silent mating-type cassette; IMP:SGD.
 GO:0006348; P:chromatin silencing at telomere; IMP:SGD.
 GO:0007059; P:chromosome segregation; IMP:SGD.
 GO:0008298; P:intracellular mRNA localization; IPI:SGD.
 GO:0045141; P:meiotic telomere clustering; IMP:SGD.
 GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IGI:SGD. 
Interpro
 IPR004087; KH_dom.
 IPR004088; KH_dom_type_1. 
Pfam
 PF00013; KH_1 
SMART
 SM00322; KH 
PROSITE
 PS50084; KH_TYPE_1 
PRINTS