CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041195
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 RAS guanyl-releasing protein 1 
Protein Synonyms/Alias
  
Gene Name
 Rasgrp1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
738QLKYAQKKIESLQLGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Complete proteome; Guanine-nucleotide releasing factor; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 760 AA 
Protein Sequence
MGTLGKAREA PRKPCHGSRA GPKARLEAKS TNSPLPAQPS LAQITQFRMM VSLGHLAKGA 60
SLDDLIDSCI QSFDADGNLC RNNQLLQVML TMHRIIISSA ELLQKVMNLY KDALEKNSPG 120
VCLKICYFVR YWITEFWIMF KMDASLTSTM EEFQDLVKAN GEETHCHLID TTQINSRDWS 180
RKLTQRIKSN TSKKRKVSLL FDHLEPEELS EHLTYLEFKS FRRISFSDYQ NYLVNSCVKE 240
NPTMERSIAL CNGISQWVQL MVLSRPTPQL RAEVFIKFIH VAQKLHQLQN FNTLMAVIGG 300
LCHSSISRLK ETSSHVPHEI NKVLGEMTEL LSSCRNYDNY RRAYGECTHF KIPILGVHLK 360
DLISLYEAMP DYLEDGKVNV QKLLALYNHI NELVQLQEMA PPLDANKDLV HLLTLSLDLY 420
YTEDEIYELS YAREPRNHRA PSVFKNYDLD QDGYISQEEF EKIAASFPFS FCVMDKDREG 480
LISRDEITAY FMRASSIYSK LGLGFPHNFQ ETTYLKPTFC DNCAGFLWGV IKQGYRCKDC 540
GMNCHKQCKD LVVFECKKRI KSPAISTENI SSVVPMSTLC PLGTKDLLHA PEEGSFIFQN 600
GEIVDHSEES KDRTIMLLGV SSQKISVRLK RTVAHKSTQT ESFPWVGGET TPGHFVLSSP 660
RKSAQGALYV HSPASPCPSP ALVRKRAFVK WENKESLIKP KPELHLRLRT YQELEQEINT 720
LKADNDALKI QLKYAQKKIE SLQLGKSNHV LAQMDHGDSA 760 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
 GO:0032862; P:activation of Rho GTPase activity; IMP:MGI.
 GO:0001816; P:cytokine production; IMP:MGI.
 GO:0002437; P:inflammatory response to antigenic stimulus; IMP:MGI.
 GO:0043303; P:mast cell degranulation; IMP:MGI.
 GO:0014066; P:regulation of phosphatidylinositol 3-kinase cascade; IMP:MGI.
 GO:0032252; P:secretory granule localization; IMP:MGI.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
 GO:0047496; P:vesicle transport along microtubule; IMP:MGI. 
Interpro
 IPR020454; DAG/PE-bd.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR000651; Ras-like_Gua-exchang_fac_N.
 IPR008937; Ras_GEF.
 IPR023578; Ras_GEF_dom.
 IPR001895; RasGRF_CDC25. 
Pfam
 PF00130; C1_1
 PF13499; EF_hand_5
 PF00617; RasGEF
 PF00618; RasGEF_N 
SMART
 SM00109; C1
 SM00147; RasGEF
 SM00229; RasGEFN 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50009; RASGEF_CAT
 PS50212; RASGEF_NTER
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS
 PR00008; DAGPEDOMAIN.