UniProt Accession

 OMPA_ECOLI; P0A910; P02934 

Genbank Protein ID

 V00307; U00096; AP009048 

Genbank Nucleotide ID

 CAA23588.1; AAC74043.1; BAA35715.1 

Protein Name

 Outer membrane protein A 

Protein Synonyms/Alias

 Outer membrane protein II* 

Gene Name

 ompA 

Gene Synonyms/Alias

 con; tolG; tut; b0957; JW0940 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
213	PAPEVQTKHFTLKSD	acetylation	[1]
231	NFNKATLKPEGQAAL	acetylation	[1]
288	VVDYLISKGIPADKI	acetylation	[1]
315	GNTCDNVKQRAALID	acetylation	[1]
335	RRVEIEVKGIKDVVT	acetylation	[1]
338	EIEVKGIKDVVTQPQ	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes. 

Sequence Annotation

 REPEAT 201 202 1.
 REPEAT 203 204 2.
 REPEAT 205 206 3.
 REPEAT 207 208 4.
 DOMAIN 210 338 OmpA-like.
 REGION 197 208 Hinge-like.
 REGION 201 208 4 X 2 AA tandem repeats of A-P.
 DISULFID 311 323  

Keyword

 3D-structure; Cell membrane; Cell outer membrane; Complete proteome; Conjugation; Direct protein sequencing; Disulfide bond; Ion transport; Membrane; Porin; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane beta strand; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 346 AA 

Protein Sequence

Gene Ontology

 GO:0009279; C:cell outer membrane; IDA:EcoliWiki.
 GO:0016021; C:integral to membrane; IDA:EcoliWiki.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0046930; C:pore complex; IEA:UniProtKB-KW.
 GO:0015288; F:porin activity; IDA:EcoCyc.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0000746; P:conjugation; IMP:EcoliWiki.
 GO:0009597; P:detection of virus; IMP:EcoliWiki.
 GO:0006811; P:ion transport; IDA:EcoliWiki.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki.
 GO:0046718; P:viral entry into host cell; IMP:EcoliWiki. 

Interpro

 IPR011250; OMP/PagP_b-brl.
 IPR006664; OMP_bac.
 IPR002368; OmpA.
 IPR006690; OMPA-like_CS.
 IPR000498; OmpA-like_TM_dom.
 IPR006665; OmpA/MotB_C. 

Pfam

 PF00691; OmpA
 PF01389; OmpA_membrane 

SMART

  

PROSITE

 PS01068; OMPA_1
 PS51123; OMPA_2 

PRINTS

 PR01021; OMPADOMAIN.
 PR01022; OUTRMMBRANEA.