CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028763
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Neb 
Protein Synonyms/Alias
  
Gene Name
 Neb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
59LAQPQPAKPVERKKVubiquitination[1]
104KENYEKAKGQPYAITubiquitination[1]
353DYEKNKGKADYNVLPubiquitination[1]
478TQEYEAIKKLDQCKDubiquitination[1]
562VYKQDWEKSKAKKFDacetylation[2]
562VYKQDWEKSKAKKFDubiquitination[1]
567WEKSKAKKFDIKVDAacetylation[2]
571KAKKFDIKVDAIPLLacetylation[2]
581AIPLLAAKANSKNASubiquitination[1]
585LAAKANSKNASDVMYacetylation[2]
649MNYCETPKYQLDTLLubiquitination[1]
657YQLDTLLKNFSEAKYubiquitination[1]
708KAEYEEDKGKCYFPQacetylation[2]
987RQHPDTLKFTSIEDAacetylation[2]
1022KGEEILHKYNLPADLacetylation[2]
1052NMYKADLKDLSKKGYacetylation[2]
1069RIDAIPIKAAKAARQubiquitination[1]
1316AIPITAAKSSRNIASubiquitination[1]
1432IQSDNVYKDEYNSFFacetylation[2]
1432IQSDNVYKDEYNSFFubiquitination[1]
1454IGSLEVEKAKKAGEAacetylation[3]
1510EGEKMKHKYTMDPELacetylation[2]
1545DWKKTLAKGYDLRPDacetylation[2]
1560AIPIVAAKSSRNIASubiquitination[1]
1814RDIASDYKYKQAYEQacetylation[2]
1814RDIASDYKYKQAYEQubiquitination[1]
1878FSVVAAKKSQEVATNubiquitination[1]
1953AMEIISEKKYRQHPDacetylation[2]
2021NAINMSDKLYKLSLEacetylation[2]
2045RTDAIPIKAAKASRDubiquitination[1]
2133NITNTNYKRLIHKYIacetylation[2]
2133NITNTNYKRLIHKYIubiquitination[1]
2186AGSLEVEKAKKATEYubiquitination[1]
2265NQTLYSQKSYRLGWEubiquitination[1]
2292AISVQLAKTSRDIASubiquitination[1]
2302RDIASDFKYKQGYRKacetylation[2]
2302RDIASDFKYKQGYRKubiquitination[1]
2347EYKKDFEKWKTKYTSacetylation[2]
2450RQPPDRNKFTSIPDAubiquitination[1]
2508NLINTSDKLYKMGYEacetylation[2]
2532PVDAIPIKAAKASREubiquitination[1]
2545REIASEYKYKEGFRKacetylation[2]
2564HIGARNIKDDPKMMWacetylation[2]
2594DFEKWKTKYSSPVDMacetylation[2]
2608MLGVVLAKKCQTLVSubiquitination[1]
2934IYRQPPDKFKFTSVTacetylation[2]
2936RQPPDKFKFTSVTDSacetylation[2]
3474IMLARQNKINYSESLubiquitination[1]
3644IGSLEVVKAKRATEIubiquitination[1]
3855NDVIQARKAYDLQSDacetylation[2]
3970ISHKLYTKGWDESKMacetylation[2]
4035LCAMHAGKIYSDREYacetylation[3]
4052EFQKWKTKFSSPVDMacetylation[2]
4617VDHVRVTKNQEMVNQubiquitination[1]
4993KALYTLPKSVDDDPNubiquitination[1]
5142PVYVQAVKSGKQLSDubiquitination[1]
5145VQAVKSGKQLSDAVYubiquitination[1]
5357VRSRHLRKLWSNYLYubiquitination[1]
5573TDAVSDVKYKEDLTWubiquitination[1]
5575AVSDVKYKEDLTWLKubiquitination[1]
5707LRTTKVNKQISDILYubiquitination[1]
5821QQSDFEYKLDREFLKubiquitination[1]
5838KLSVTDDKDMVLALRubiquitination[1]
5854SLIESDLKYKEKHVKubiquitination[1]
5984VADRPDIKKATQAAKacetylation[3]
5991KKATQAAKQASEVEYubiquitination[1]
6050KTPKYNPKDSQLYKTubiquitination[1]
6069NNLASEVKYKADLKKubiquitination[1]
6238TPDMLRAKNATQILNubiquitination[1]
6247ATQILNEKEYKRDLEubiquitination[1]
6286TDIASQIKYKQSAEMubiquitination[1]
6675QRHISTVKYHEDFEKubiquitination[1]
6684HEDFEKHKGCFTPVVubiquitination[1]
6701PITERVKKNTQDFSDubiquitination[1]
6724KVVEMEQKRNDQDQDubiquitination[1]
6790SISGGEEKSEHSEAAubiquitination[1]
6819SATSTAYKHVKTTQLubiquitination[1]
6822STAYKHVKTTQLPQQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 6909 AA 
Protein Sequence
MADEEEYEEV IEYYTEETVY EEVPGETITE VYETTTTRTS DYGQSETATP ALAQPQPAKP 60
VERKKVIRKK VDSSKFMTPY IQHSQKMQDL FSSNKYKENY EKAKGQPYAI TSDTPELRRI 120
KKVQDQLSEV KYRMDGDVAK TICHVDEKAK DIEHAKKVSQ QVSKVLYKQN WEDTKDKYLL 180
PPDAPELVQA VKNTAMFSKK LYTEDWEADK ALFYPYNDSP ELRRVAQAQK ALSDIAYKKG 240
LTEQQTQFTS LPDPPEVEFA KKVTNQVSKQ KYKEDYEKKV KGKWSETPCF EIATARMNAD 300
NLSSRKYQED FENMKDQIYF MQTETPEYKM NKQAGVAASK VKYKQDYEKN KGKADYNVLP 360
ASENPLLRQL KTAGNVLSDK LYKENYEKTK ARSINYCETP KFQLDTVLQN FSSDTKYKDS 420
YLKNILGHYV GSFEDPYHTH CMKVTAQNSD KNYKAEYEED RGKGFFPQTI TQEYEAIKKL 480
DQCKDHAYKV HPDKTKFTQV TDSPVLVQAQ VNSKQLSDLN YKAKHESEKF KCHIPPDAPA 540
FIQHRVNAYN LSDNVYKQDW EKSKAKKFDI KVDAIPLLAA KANSKNASDV MYKKDYEKSK 600
GKMIGALSIN DDPKMLHSLK TAKNQSDRLY RENYEKTKAK SMNYCETPKY QLDTLLKNFS 660
EAKYKDSYVK NMLGHYVGSF EDPYHTHCMK VSAQNSDKSY KAEYEEDKGK CYFPQTITQE 720
YESIKKLDQC KDHTYKVHPD KTRFTAVTDT PVLLQAQLNT KQLSDLNYKA KHEGEKFKCS 780
VPADAPEFIQ HRVNAYNLSD NVYKHDWEKS KAKKFDIKVD AIPLLAAKAN SKNASDVMYK 840
KDYEKSKGKM IGALSINDDP KMLHSLKTAK NQSDREYRKD YEKSKTIYTA PLDMIQVTQA 900
KKSQAIASDV DYKHVLHNYS YPPDSINVDL AKKAYALQSD VEYKADYNSW MKGCGWVPFG 960
SLEMEKAKRA SEILNEKKYR QHPDTLKFTS IEDAPITVQS KINQAQRSDI AYKAKGEEIL 1020
HKYNLPADLP QFIQAKVNAY NISENMYKAD LKDLSKKGYD LRIDAIPIKA AKAARQAASD 1080
IHYKKDYEKA KGKMVGFQSL QDDPKLVHYM NVAKIQSDRE YKKDYEKTKT KYNTPHDMFD 1140
VVAAKKAQDV ISNTNYKHSL HHYTYLPDAM DLELSKNMMH IQSDNAYKED YNTWMKGIGW 1200
IPIGSLDQEK VKKAGDALSE KKYRQHPDTL KFTSIVDSPV MVQAKQNTQQ ASDILYKAKG 1260
EDVKHKYTLN PDLPQFLQAK CNAYNISDVC YKRDWHDLIA KGNNVLADAI PITAAKSSRN 1320
IASDYKYKEA YEKAKGKHVG FRSLQDDPKL VHYMNVAKLQ SDREYKKNYE NTKTSYHTPG 1380
DMVSITAARM AQDVATNVNY KQPLHHYTYL PDALSLEHTR NANQIQSDNV YKDEYNSFFK 1440
GIGWIPIGSL EVEKAKKAGE ALNERKYRQH PDTIKFTSVP DSMGMVLAQQ NTKQLSDLNY 1500
KVEGEKMKHK YTMDPELPQF IQAKVNAINM SDAHYKADWK KTLAKGYDLR PDAIPIVAAK 1560
SSRNIASDCK YKEAYEKARG KQIGFLSLQD DPKLVHYMNV AKIQSDREYK KGYEASKTRY 1620
HTPLDMFSVT AAKKSQEVAT NSNYRQPYHN YTLLPDALNV EHSRNAMQIQ SDNLYKSDFT 1680
HWMKGIGWVP IDSLEVEKAK KAGEILSERK YRQHPEKLKF TYSMDTMEQA LNKSNKLTMD 1740
KRLYTEKWNK DKTSIHVMPD TPDILLSRVN QITMSDKLYK AGWEEEKTKG YDLKPDAIAI 1800
KAAKASRDIA SDYKYKQAYE QSKGKHIGFR SLEDDPKLVH FMQVAKIQSD REYKKGYEKS 1860
KTSFHTPVDM FSVVAAKKSQ EVATNANYRN IIHTYNMLPD AMSFELAKNM MQIQSDNQYK 1920
ADYADFMKGI GWLPLGSLEA EKNKKAMEII SEKKYRQHPD TLKYSTLMDS MNMVLAQNNA 1980
KIMNKNLYKQ AWEADKTKIH IMPDIPEIVL AKANAINMSD KLYKLSLEES RKKGYDLRTD 2040
AIPIKAAKAS RDIASDYKYK HSYEKEKGKM VGFRSLEDDP KLVHSMQVAK MQSDREYKKN 2100
YEKTKTSYHT PADMLSVTAA KDAQANITNT NYKRLIHKYI LLPDAMNIEL TRNMNHIQSD 2160
NEYKQDYREW YRGLGWSPAG SLEVEKAKKA TEYASDQKYR QHPSTFQFKK LTDSMDMVLA 2220
KQNAHTMNKH LYTIDWNKDK TKIHVMPDTP DILQAKQNQT LYSQKSYRLG WEEALKKGYD 2280
LPVDAISVQL AKTSRDIASD FKYKQGYRKQ LGHHIGFLSV QDDPKLVLSM NVAKMQSDRE 2340
YKKDFEKWKT KYTSPVDMLG VVLAKKCQAL VSDADYRNYL HQWTCLPDQN DVIQAKKVYE 2400
LQSENMYKSD LEWLRGIGWS PLGSLEAEKN KRASEIISEK KYRQPPDRNK FTSIPDAMDI 2460
VLAKTNAKNR SDRLYREAWD KDKTQIHIMP DTPDIILAKA NLINTSDKLY KMGYEELKKK 2520
GYDLPVDAIP IKAAKASREI ASEYKYKEGF RKQLGHHIGA RNIKDDPKMM WSMHVAKIQS 2580
DREYKKDFEK WKTKYSSPVD MLGVVLAKKC QTLVSDADYR NYLHQWTCLP DQNDVIHARQ 2640
AYDLQSDNVY KADLQWLKGI GWIPSGSLED EKNKRATQIL SDHVYRQHPN KFKFSSLMDS 2700
MPMVLAKNNA ITMNHHLYTE AWNKDKTTVH IMPDTPEVIL AKQNKVNYSE KLYKLGLEEA 2760
KRKGYDMRLD AIPIKTAKAS RDIASDFKYK EGYRKQLGHH IGARGIHDDP KMMWSMHVAK 2820
IQSDREYKKD FEKWKTKYSS PVDMLGVVLA KKCQTLVSDA DYRNYLHQWT CLPDQNDVIH 2880
ARQAYDLQSD NMYKSDLQWM RGIGWVPIGS LDVEKCKRAT EILSDKIYRQ PPDKFKFTSV 2940
TDSLEQVLAK NNAITMNKRL YTEAWDKDKT QIHIMPDTPE IMLARMNKVN YSESLYKLAN 3000
EEAKKKGYDL RSDAIPIVAA KASRDIASDY KYKDGYRKQL GHHIGARNIK DDPKMMWSMH 3060
VAKIQSDREY KKDFEKWKTK YSSPVDMLGV VLAKKCQILV SDIDYKHPLH EWTCLPDQND 3120
VIHARQAYDL QSDNVYKSDL QWMRGIGWVP IGSLDVVKCK RAAEILSDNI YRQPPNKFKF 3180
TSVTDSLEQV LAKSNALNMN KRLYTEAWDK DKIQIHVMPD TPEIMLARQN RINYSESLYK 3240
LANEEAKKKG YDLRVDAIPI VAAKASRDIA SDYKYKVGYR KQLGHHIGAR NIEDDPKMMW 3300
SMHVAKIQSD REYKKDFEKW KTKYSSPVDM LGVVLAKKCQ TLVSDVDYRN YLHQWTCLPD 3360
QNDVIHARQA YDLQSDNVYK SDLQWMRGIG WVPIGSLDVV KCKRAAEILS DNIYRQPPNK 3420
FKFTSVTDSL EQVLAKSNAL NMNKRLYTEA WDKDKTQIHI MPDTPEIMLA RQNKINYSES 3480
LYRQAMEEAK KEGYDLRSDA IPIVAAKASR DIASDYKYKE AYRKQLGHHI GARAIHDDPK 3540
MMWSLHIAKV QSDREYKKEF EKYKTRYSSP VDMLGIVLAK KCQTLVSDVD YKHPLHEWTC 3600
LPDQNDVIQA RKAYDLQSDN LYKADLEWMK GIGWVPIGSL EVVKAKRATE ILSDNIYRQR 3660
PDTLKFTSIT DSLEQVLAKN NAITMNKRLY TEAWDNDKKT IHVMPDTPEI MLAKLNRINY 3720
SDKLYKVSLE EARRQGYDLR VDAIPIRSAK ASREIASDYK YKEGYRKQLG HHIGARNIKD 3780
DPKMMWSMHV AKIQSDREYK KDFEKWKTKY SSPVDMLGVV LAKKCQILVS DIDYKHPLHE 3840
WTCLPDQNDV IQARKAYDLQ SDAVYKADLE WLRGIGWVPI GSVEVEKVKR AGEILSDRKY 3900
RQPADQLKFT CITDTPEIVL AKSNAITMSK HLYTEAWDAD KASIHVMPDT PEILLAKSNS 3960
ANISHKLYTK GWDESKMKDY DLREDAISIK SAKASRDIAS DYKYKEAYEK QKGHHIGAQS 4020
VEDDPRILCA MHAGKIYSDR EYKKEFQKWK TKFSSPVDML GVVLAKKCQT LVSDVDYRNY 4080
LHNWTCLPDQ NDIIQAKKAY ELQSDAIYKA DLEWLRGIGW MPEGSPEVLR VKNAQEILCD 4140
SVYRTPVVKL KYTSIVDTPE VVLAKSNAEN ISIPKYREVW DKDKTSIHIM PDTPEINLAR 4200
ANALNVSNKL YREGWDEVKM SCDVRLDAIP IQAAKASREI ASDYKYKLDH EKQKGHYVGT 4260
LTARDDNKIR WALIAGKIQN EREYRLQWAK WKTKFQSPVD MLSILHSKKC QTLVSDIDYR 4320
NYLHEWTCMP DQNDVIQAKK AYELQSDAVY KADLEWLRGI GWMPNDSVSV NHAKHAADIF 4380
SEKKYRTKIE TLNFTPVDDR VDYVTAKQSS EIRDDIKYRK DWNAIKSKYT LTETPLLHTA 4440
QEAARILDQY LYKEGWEKQK ATGYILPPDA VPFVHAHHSS DVQSELKYKA EHVKQRGHYV 4500
GVPTMRDDPK LVWFEHAGQI QNDRLYKESY HKSKAKINIP ADMVSVVAAK EGQNLVSDID 4560
YRQYLHQWTC HPDQNDVIQA KIAYDLQSDN VYKADLEWLR GIGWIPLDSV DHVRVTKNQE 4620
MVNQIKYKKD ALANYPNFTS VEDPPEIVLA KINSVNQSDV KYKETFNKAK GKYIFSPDTP 4680
YISHSKDMGK LYSTILYKGA WEGTKAYGYT LDERYIPIVG AKHADLVNSE LKYKETYEKQ 4740
KGHYLAGKEI SEFPGVVHCL DFQQMRSALN YRRDYEDTKA NVHIPNDMMN HVLAKRCQYI 4800
LSDLEYRHYF HQWTSLPEEP NVIRARNAQE ILSDNVYKDD LNWLKGIGCY VWDTPQILHA 4860
KKSYDLQSQL QYTAASKENL QNYNLVTDTP VYVTALQSGI NASEVKYKEN YHQIKDKYTT 4920
VLETADYDRT KHLKSLYSSN IYKEAWDKVK ATSYNLPTST LSLTHAKNQK HLASHIKYRE 4980
EYEKFKALYT LPKSVDDDPN TARCLRVGKL NIDRLYRSVY EKNKMKINIV PDMVEMVTAK 5040
DSQKKVSEID YRLHLHEWIC HPDLQVNSHV RKVTDQISDI VYKDDLTWLK GIGCYVWDTP 5100
EILHAKHAYD LRNDIKYKAH VQKTRNDYKL VTDTPVYVQA VKSGKQLSDA VYHYDYVHSV 5160
RGKVAPTTKT VDLDRALHAY KLQSENLYKK GLRFLPTGYR LPVDTPHFNH TKDTRYMSSY 5220
FKYKEAYEHI KANGYTLGPK DVPFVHVRRV NNVTSERLYR ELYHKLKDKI HTTPDTPEIR 5280
QVKKTQEAVS ELIYKSDFFK MQGHMISLPY TPQVLHCRYV GDITSDIKYK EDLQILKGLG 5340
CFLYDTPDMV RSRHLRKLWS NYLYTDNARK MRDKYKVVLD TPEYRKVQEL KTHLSELVYR 5400
ASGKKQKSIF TSVPDTPDLL RAKRGQKLQS QYLYVELATK ERPHHHAGNQ TTALQHAKDV 5460
KDMVSEKKYK IQYEKMKDKY TPVADTPILI RAKRAYWNAS DLRYKETFQK TKGRYHTVKD 5520
ALDIVYHRKV TDDISKVKYK ENYMSQLGIW SSIPDRPEHF HHRAVTDAVS DVKYKEDLTW 5580
LKGIGCYAYD TPDLTLAEQN KTLYSKYKYK EVFERTKSNF KYVADCPINR HFKYATQLMN 5640
EKKYRADYEQ RKDKYHLVVD EPRHLLAKTA GDQISQIKYR KKYEKSKDKF TSVVDTPEHL 5700
RTTKVNKQIS DILYKLEYNK ARPRGYTTIH DTPMLLHVRK VKDEVSDLKY KEVYQRNKSN 5760
CTIKPDAVHI KAAKDAYKVN TNLDYKKQYE ANKAYWKWTP DRPDFIQAAK SSLQQSDFEY 5820
KLDREFLKGC KLSVTDDKDM VLALRNSLIE SDLKYKEKHV KERGSCHAVP DTPQILLAKT 5880
VSNLVSENKY KDHVKKHLAQ GSYTTLPETR DTVHVKAVTK HVSDTNYKKK FVKEKGKSNY 5940
SIMQEPPEVK HAMEVAKKQS DVAYKKDAKE NLHYTTVADR PDIKKATQAA KQASEVEYRA 6000
KHRKEGSHGL SMLGRPDIEM AKKAAKLSSQ VKYRENFDKE KGKTPKYNPK DSQLYKTMKD 6060
ANNLASEVKY KADLKKLHKP VTDMKESLIM HHVLNTSQLA SSYQYKKNYE KSKGHYHTIP 6120
DNLEQLHHRE ATELQSIVKY KEKYEKERGK PMLDFETPTY ITAKESQQMQ SGKEYRKDYE 6180
ESIKGRNLTG LEVTPALLHV RHATKIASEK EYRKDLEESI RGRGLTEMED TPDMLRAKNA 6240
TQILNEKEYK RDLELEVKGR GLNAMANETP DFMRARNATD IASQIKYKQS AEMEKANFTS 6300
VVDTPEIIHA QQVKNLSSQK KYKEDAEKSM SYYETVLDTP EMQRVRENQK NFSLLQYQCD 6360
LKNSKGKITV VQDTPEILRV KENQKNFSSV LYKEDVSPGT AIGKTPEMLR VKQTQDHISS 6420
VKYKEAIGQG TPIPDLPEVK RVKETQKHIS SVMYKENPGT GIPTTVTPEI ERVKRNQENF 6480
SSVLYKESLG KGTPTAITPE MERVKRNQEN FSSILYKENL SKGTPLPVTP EMERAKRNQE 6540
NFSSVLYKEN VGKATPTPVT PEMQRVKRNQ ENISSVLYKE NMGKATPTPF TPEMERVKRN 6600
QENFSSVLYK ENMRKATPTP VTPDMERAKR NQENISSVLY SDSFRKQIQG KAAYVLDTPE 6660
MRRVRETQRH ISTVKYHEDF EKHKGCFTPV VTDPITERVK KNTQDFSDIN YRGIQRKVVE 6720
MEQKRNDQDQ DTITGLRVWR TNPGSVFDYD PAEDNIQSRS LHMINVQAQR RSRDQSRSAS 6780
ALSISGGEEK SEHSEAADQR LSTYSDGGAF FSATSTAYKH VKTTQLPQQR SSSVATQQTT 6840
LSSIPSHPST AGKIFRAIYD YIAADADEVS FKDGDAIVNA QAIDEGWMYG TVQRTGRTGM 6900
LPANYVEAI 6909 
Gene Ontology
 GO:0043234; C:protein complex; ISO:MGI.
 GO:0005865; C:striated muscle thin filament; TAS:MGI.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0030832; P:regulation of actin filament length; TAS:MGI.
 GO:0045214; P:sarcomere organization; TAS:MGI. 
Interpro
 IPR013998; Nebulin.
 IPR000900; Nebulin_35r-motif.
 IPR001452; SH3_domain. 
Pfam
 PF00880; Nebulin
 PF00018; SH3_1 
SMART
 SM00227; NEBU
 SM00326; SH3 
PROSITE
 PS51216; NEBULIN
 PS50002; SH3 
PRINTS
 PR00510; NEBULIN.