CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038405
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Nup153 
Protein Synonyms/Alias
  
Gene Name
 Nup153 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
16GGGGGGGKIRTRRCHacetylation[1]
28RCHQGPVKPYQQGRPubiquitination[2]
264DSPFYPGKTTYGGAAubiquitination[2]
295VRRQMKAKQLNAQSYubiquitination[2]
385TNRTVYFKPSLTPSGacetylation[1]
385TNRTVYFKPSLTPSGubiquitination[2]
597EDPFTPAKILREGSVacetylation[3]
597EDPFTPAKILREGSVubiquitination[2]
609GSVLDILKTPGFASPubiquitination[2]
698TGTGTPSKSDKPASTacetylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1462 AA 
Protein Sequence
MASEAGGIGG GGGGGKIRTR RCHQGPVKPY QQGRPQHQGI LSRVTESVKN IVPGWLQRYF 60
NKSENACSCS PDADEVPPWP ENREDEHAIY ADENTNTDDG RITPDPAGSN TEEPSTTSTA 120
SNYPDVLTRP SLHRSHLNFS VLESPALHCQ PSTSSAFPIG SSGFSLVKEI KDSTSQHDDD 180
NISTTSGFSS RASEKDIAVS KNTSLPPLWS PEAERSHSLS QHTAISSKKP AFNLSAFGTL 240
STSLGNSSIL KTSQLGDSPF YPGKTTYGGA AAAVRQNKVR STPYQAPVRR QMKAKQLNAQ 300
SYGVTSSTAR RILQSLEKMS SPLADAKRIP SAVSSPLNSP LDRSGIDNTV FQAKKEKVDS 360
QYPPVQRLMT PKPVSIATNR TVYFKPSLTP SGDLRKTNQR IDKKNSTVDE KSISRQNREQ 420
ESGFSYPNFS IPAANGLSSG VGGGGGKMRR ERTHFVAPKP PENEEVEAPL LPQISLPISS 480
SSLPTFSFSS PVTSASPSPV SSSQPLPNKV QMTSLGSTGS PVFTFSSPIV KSTQAAVLPP 540
ASIGFTFSVP LAKTEFSGSN SSSETVLSSS AQDITAVNSS SYKKRSAPCE DPFTPAKILR 600
EGSVLDILKT PGFASPKVDS PALQPTTTSS IVYTRPAIST FSSSGIEYGE SLKAGSSWQC 660
DTCLLQNKVT DNKCIACQAA KLPLKETAKQ TGTGTPSKSD KPASTSGTGF GDKFKPAIGT 720
WDCDTCLVQN KPEAVKCVAC ETPKPGTGVK RALTLTVASE SPVTASSSTT VTTGTLGFGD 780
KFKRPVGSWE CPVCCVCNKA EDNRCVSCTS EKPGLVSASS SSPAPVSLSS GGCLGLDKFK 840
KPEGSWDCEV CLVQNKADSA KCIACESAKP GTKSEFKGFG TSSSLNPAPS AFKFGIPSSS 900
SGLSQTLTST GNFKFGDQGG FKLGTSSDSG STNTMNTNFK FSKPTGDFKF GVLSDSKPEE 960
VKNDNKNDNF QFGSSSGLTN PASSAPFQFG VSTLGQQEKK EELPKSSPAG FSFGAGVNNP 1020
PNAAIDTTAT SENKSGFNFG TLDTKSVSVT PFTYKTTEAK KEDAPATKGG FTFGKVGSSS 1080
LPSSSMFVLG RTEEKQQEPV TSTSLVFGKK ADSEEPKCQP VFSFGNSEQT KDESSKPTFS 1140
FSVAKPSGKE SEQLAKATFA FGNQTNTTTD QGAAKPVFSF LNSSSSSSSA PATSSSGGIF 1200
GSSTSSSNPP VAAFVFGQAS NPVSSSAFGN AAESSTSQSL LFPQESEPAT TSSTAPAASP 1260
FVFGTGASSN SVSSGFTFGA TTTSSSSGSS FVFGTGHSAP SASPAFGANQ TPTFGQSQGA 1320
SQPNPPSFGS ISSSTALFSA GSQPVPPPIF GTVSSSSQPP VFGQQPSQSA FGSGTANASS 1380
VFQFGSSTTN FNFTNNNPSG VFTFGASPST PAASAQPSGS GVFSFSQSPA SFTVGSNGKN 1440
MFSSSGTSVS GRKIKTAVRR KK 1462 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0042405; C:nuclear inclusion body; IEA:Compara.
 GO:0031965; C:nuclear membrane; IEA:Compara.
 GO:0034399; C:nuclear periphery; IEA:Compara.
 GO:0044615; C:nuclear pore nuclear basket; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005487; F:nucleocytoplasmic transporter activity; IEA:Compara.
 GO:0017056; F:structural constituent of nuclear pore; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0046832; P:negative regulation of RNA export from nucleus; IEA:Compara.
 GO:0051292; P:nuclear pore complex assembly; IEA:Compara. 
Interpro
 IPR026054; Nucleoporin.
 IPR013913; Nucleoporin_Nup153.
 IPR018892; Retro-transposon_transp_CS.
 IPR001876; Znf_RanBP2. 
Pfam
 PF08604; Nup153
 PF10599; Nup_retrotrp_bd
 PF00641; zf-RanBP 
SMART
 SM00547; ZnF_RBZ 
PROSITE
 PS01358; ZF_RANBP2_1
 PS50199; ZF_RANBP2_2 
PRINTS