UniProt Accession

 SEC66_YEAST; P33754; D6VQG7 

Genbank Protein ID

 U00797; X72224; X74437; Z36040; AY558125; BK006936 

Genbank Nucleotide ID

 AAA18910.1; CAA51025.1; CAA52451.1; CAA85132.1; AAS56451.1; DAA07287.1 

Protein Name

 Translocation protein SEC66 

Protein Synonyms/Alias

 Protein HSS1; Sec62/63 complex 31.5 kDa subunit 

Gene Name

 SEC66 

Gene Synonyms/Alias

 HSS1; SEC71; YBR171W; YBR1232 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
185	RRYQSILKRKEVCIK	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC66 is required to attach or retain SEC72 in the SEC63 complex. It is essential for growth at elevated temperatures. 

Sequence Annotation

 CARBOHYD 5 5 N-linked (GlcNAc...) (Probable).
 CARBOHYD 12 12 N-linked (GlcNAc...) (Probable).  

Keyword

 Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Membrane; Protein transport; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 206 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0031207; C:Sec62/Sec63 complex; IPI:SGD.
 GO:0008565; F:protein transporter activity; TAS:SGD.
 GO:0030447; P:filamentous growth; IMP:SGD.
 GO:0031204; P:posttranslational protein targeting to membrane, translocation; IDA:SGD. 

Interpro

 IPR018624; Sec62/63_Sec66. 

Pfam

 PF09802; Sec66 

SMART

  

PROSITE

  

PRINTS