UniProt Accession

 NDKA1_XENLA; P70010; Q68FI7 

Genbank Protein ID

 X97900; BC079795 

Genbank Nucleotide ID

 CAA66474.1; AAH79795.1 

Protein Name

 Nucleoside diphosphate kinase A1 

Protein Synonyms/Alias

 NDK A1; NDP kinase A1; NM23/nucleoside diphosphate kinase A1 

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Xenopus laevis (African clawed frog) 

NCBI Taxa ID

 8355 

Lysine Modification

Position	Peptide	Type	References
101	ETNPADSKPGTIRGD	acetylation	[1]

Reference

 [1] A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of Sirt1 in the metabolic regulation of caspase-2.
 Andersen JL, Thompson JW, Lindblom KR, Johnson ES, Yang CS, Lilley LR, Freel CD, Moseley MA, Kornbluth S.
 Mol Cell. 2011 Sep 2;43(5):834-42. [PMID: 21884983] 

Functional Description

 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. 

Sequence Annotation

 ACT_SITE 119 119 Pros-phosphohistidine intermediate (By
 BINDING 13 13 ATP (By similarity).
 BINDING 61 61 ATP (By similarity).
 BINDING 89 89 ATP (By similarity).
 BINDING 95 95 ATP (By similarity).
 BINDING 106 106 ATP (By similarity).
 BINDING 116 116 ATP (By similarity).  

Keyword

 ATP-binding; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide metabolism; Nucleotide-binding; Phosphoprotein; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 154 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004550; F:nucleoside diphosphate kinase activity; IEA:EC.
 GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
 GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
 GO:0006228; P:UTP biosynthetic process; IEA:InterPro. 

Interpro

 IPR001564; Nucleoside_diP_kinase.
 IPR023005; Nucleoside_diP_kinase_AS. 

Pfam

 PF00334; NDK 

SMART

 SM00562; NDK 

PROSITE

 PS00469; NDP_KINASES 

PRINTS

 PR01243; NUCDPKINASE.