UniProt Accession

 CD33_HUMAN; P20138; B4E3P8; C9JEN7; F8WAL2; Q8TD24 

Genbank Protein ID

 M23197; AY040541; AY162464; AK304810; AC063977; CH471135; BC028152 

Genbank Nucleotide ID

 AAA51948.1; AAK83654.1; BAG65560.1; EAW71996.1; AAH28152.1 

Protein Name

 Myeloid cell surface antigen CD33 

Protein Synonyms/Alias

 Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD33 

Gene Name

 CD33 

Gene Synonyms/Alias

 SIGLEC3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
77	DSPVATNKLDQEVQE	ubiquitination	[1]
250	FPGDGSGKQETRAGV	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). 

Sequence Annotation

 DOMAIN 19 135 Ig-like V-type.
 DOMAIN 145 228 Ig-like C2-type.
 MOTIF 338 343 ITIM motif 1.
 MOTIF 356 361 ITIM motif 2.
 BINDING 119 119 Sialic acid (By similarity).
 MOD_RES 340 340 Phosphotyrosine.
 MOD_RES 358 358 Phosphotyrosine.
 CARBOHYD 100 100 N-linked (GlcNAc...) (Potential).
 CARBOHYD 113 113 N-linked (GlcNAc...) (Potential).
 CARBOHYD 160 160 N-linked (GlcNAc...) (Potential).
 CARBOHYD 209 209 N-linked (GlcNAc...) (Potential).
 CARBOHYD 230 230 N-linked (GlcNAc...) (Potential).
 DISULFID 36 169 By similarity.
 DISULFID 41 101 By similarity.
 DISULFID 163 212 Potential.  

Keyword

 Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Lectin; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 364 AA 

Protein Sequence

Gene Ontology

 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0004872; F:receptor activity; TAS:ProtInc.
 GO:0007155; P:cell adhesion; NAS:ProtInc.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
 GO:0007165; P:signal transduction; TAS:ProtInc. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set.
 IPR013151; Immunoglobulin. 

Pfam

 PF00047; ig
 PF07686; V-set 

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE 

PRINTS