CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022088
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 72 kDa inositol polyphosphate 5-phosphatase 
Protein Synonyms/Alias
 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Phosphatidylinositol polyphosphate 5-phosphatase type IV 
Gene Name
 INPP5E 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
254DCSLRSAKSSFSLLAubiquitination[1]
521MRKGSIFKGFQEPDIubiquitination[2, 3]
565VLYRSRHKGDICPVSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2. Specific for lipid substrates, inactive towards water soluble inositol phosphates. 
Sequence Annotation
 REPEAT 10 13 1.
 REPEAT 15 18 2.
 REPEAT 28 31 3.
 REPEAT 39 42 4.
 REPEAT 55 58 5.
 REPEAT 69 71 6.
 REPEAT 72 74 7.
 REPEAT 75 78 8.
 REPEAT 121 124 9.
 REPEAT 169 172 10.
 REPEAT 183 185 11.
 REPEAT 190 193 12.
 REPEAT 236 239 13.
 REGION 10 242 13 X 4 AA repeats of P-X-X-P.
 MOD_RES 99 99 Phosphoserine.
 MOD_RES 241 241 Phosphoserine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Cell projection; Ciliopathy; Cilium; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Golgi apparatus; Hydrolase; Joubert syndrome; Lipid metabolism; Membrane; Mental retardation; Obesity; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 644 AA 
Protein Sequence
MPSKAENLRP SEPAPQPPEG RTLQGQLPGA PPAQRAGSPP DAPGSESPAL ACSTPATPSG 60
EDPPARAAPI APRPPARPRL ERALSLDDKG WRRRRFRGSQ EDLEARNGTS PSRGSVQSEG 120
PGAPAHSCSP PCLSTSLQEI PKSRGVLSSE RGSPSSGGNP LSGVASSSPN LPHRDAAVAG 180
SSPRLPSLLP PRPPPALSLD IASDSLRTAN KVDSDLADYK LRAQPLLVRA HSSLGPGRPR 240
SPLACDDCSL RSAKSSFSLL APIRSKDVRS RSYLEGSLLA SGALLGADEL ARYFPDRNVA 300
LFVATWNMQG QKELPPSLDE FLLPAEADYA QDLYVIGVQE GCSDRREWET RLQETLGPHY 360
VLLSSAAHGV LYMSLFIRRD LIWFCSEVEC STVTTRIVSQ IKTKGALGIS FTFFGTSFLF 420
ITSHFTSGDG KVAERLLDYT RTVQALVLPR NVPDTNPYRS SAADVTTRFD EVFWFGDFNF 480
RLSGGRTVVD ALLCQGLVVD VPALLQHDQL IREMRKGSIF KGFQEPDIHF LPSYKFDIGK 540
DTYDSTSKQR TPSYTDRVLY RSRHKGDICP VSYSSCPGIK TSDHRPVYGL FRVKVRPGRD 600
NIPLAAGKFD RELYLLGIKR RISKEIQRQQ ALQSQNSSTI CSVS 644 
Gene Ontology
 GO:0035085; C:cilium axoneme; IDA:UniProtKB.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
 GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; TAS:UniProtKB.
 GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC.
 GO:0046855; P:inositol phosphate dephosphorylation; IEA:Compara.
 GO:0006661; P:phosphatidylinositol biosynthetic process; TAS:Reactome.
 GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 
Interpro
 IPR005135; Endo/exonuclease/phosphatase.
 IPR000300; IPPc. 
Pfam
 PF03372; Exo_endo_phos 
SMART
 SM00128; IPPc 
PROSITE
  
PRINTS