UniProt Accession

 CATS_HUMAN; P25774; B4DWC9; D3DV05; Q5T5I0; Q6FHS5; Q9BUG3 

Genbank Protein ID

 S93414; M86553; M90696; U07374; U07370; U07371; U07372; U07373; CR541676; AK301472; AK314482; AL356292; CH471121; CH471121; BC002642 

Genbank Nucleotide ID

 AAB22005.1; AAA35655.1; AAC37592.1; AAB60643.2; AAB60643.2; AAB60643.2; AAB60643.2; AAB60643.2; CAG46477.1; BAG62991.1; BAG37086.1; CAI13657.1; EAW53518.1; EAW53519.1; AAH02642.1 

Protein Name

 Cathepsin S 

Protein Synonyms/Alias

  

Gene Name

 CTSS 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
42	YGKQYKEKNEEAVRR	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. 

Sequence Annotation

 ACT_SITE 139 139 By similarity.
 ACT_SITE 278 278 By similarity.
 ACT_SITE 298 298 By similarity.
 CARBOHYD 104 104 N-linked (GlcNAc...) (Potential).
 DISULFID 126 224
 DISULFID 136 180
 DISULFID 170 213
 DISULFID 272 320  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Polymorphism; Protease; Reference proteome; Signal; Thiol protease; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 331 AA 

Protein Sequence

Gene Ontology

 GO:0036021; C:endolysosome lumen; TAS:Reactome.
 GO:0005576; C:extracellular region; NAS:UniProtKB.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0004197; F:cysteine-type endopeptidase activity; TAS:ProtInc.
 GO:0002250; P:adaptive immune response; IEP:UniProtKB.
 GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0097067; P:cellular response to thyroid hormone stimulus; IEP:UniProtKB.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0006508; P:proteolysis; TAS:ProtInc.
 GO:0002224; P:toll-like receptor signaling pathway; TAS:Reactome. 

Interpro

 IPR025661; Pept_asp_AS.
 IPR000169; Pept_cys_AS.
 IPR025660; Pept_his_AS.
 IPR013128; Peptidase_C1A.
 IPR000668; Peptidase_C1A_C.
 IPR013201; Prot_inhib_I29. 

Pfam

 PF08246; Inhibitor_I29
 PF00112; Peptidase_C1 

SMART

 SM00848; Inhibitor_I29
 SM00645; Pept_C1 

PROSITE

 PS00640; THIOL_PROTEASE_ASN
 PS00139; THIOL_PROTEASE_CYS
 PS00639; THIOL_PROTEASE_HIS 

PRINTS

 PR00705; PAPAIN.