UniProt Accession

 TNF10_HUMAN; P50591; A1Y9B3 

Genbank Protein ID

 U37518; U57059; DQ848564; EU183231; AK296085; AC007919; AC016938; BC032722 

Genbank Nucleotide ID

 AAC50332.1; AAB01233.1; ABI24016.1; ABW24658.1; BAG58840.1; AAH32722.1 

Protein Name

 Tumor necrosis factor ligand superfamily member 10 

Protein Synonyms/Alias

 Apo-2 ligand; Apo-2L; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD253 

Gene Name

 TNFSF10 

Gene Synonyms/Alias

 APO2L; TRAIL 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
106	TISTVQEKQQNISPL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. 

Sequence Annotation

 METAL 230 230 Zinc.  

Keyword

 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Cytokine; Membrane; Metal-binding; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 281 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005102; F:receptor binding; TAS:ProtInc.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:Reactome.
 GO:0097190; P:apoptotic signaling pathway; TAS:Reactome.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0006955; P:immune response; IEA:InterPro.
 GO:0006917; P:induction of apoptosis; TAS:ProtInc.
 GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IDA:UniProtKB.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEP:UniProtKB.
 GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IDA:UniProtKB. 

Interpro

 IPR006052; TNF.
 IPR021184; TNF_CS.
 IPR017355; TNF_ligand_10/11.
 IPR008983; Tumour_necrosis_fac-like_dom. 

Pfam

 PF00229; TNF 

SMART

 SM00207; TNF 

PROSITE

 PS00251; TNF_1
 PS50049; TNF_2 

PRINTS