| Tag | Content |
|---|
| CPLM ID | CPLM-013776 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nuclear speckle splicing regulatory protein 1 |
Protein Synonyms/Alias | Coiled-coil domain-containing protein 55; Nuclear speckle-related protein 70; NSrp70 |
Gene Name | Nsrp1 |
Gene Synonyms/Alias | Ccdc55; Nsrp70 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 277 | EDTGASMKHPKHHKN | acetylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | RNA-binding protein that mediates pre-mRNA alternative splicing regulation (By similarity). |
Sequence Annotation | REGION 105 169 Necessary for alternative splicing
MOD_RES 27 27 Phosphoserine (By similarity).
MOD_RES 31 31 Phosphoserine.
MOD_RES 33 33 Phosphoserine.
MOD_RES 254 254 Phosphoserine (By similarity).
MOD_RES 255 255 Phosphoserine (By similarity). |
Keyword | Coiled coil; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 542 AA |
Protein Sequence | MAIPGRQYGL ILPKKTQPLH RVLQKPSVFG SDSDDDETSV SESLQREAAK KQAMKQTKLE 60
IQKALAEDST VYEYDSVYDE MQKKKEENNP KLLPGKDRKP KYIHNLLKAV EIRKKEQEKR 120
MEKKIQRERE MENGEFDDKE AFVTSAYKKK LEERAEEEER EKRAAALEAH LDVTKQKDLS 180
GFYRHLLNQA VGEEAAPKSS FREARTVIKE EKLRGYPDET NSESRPPQQS CVLQRGAQEA 240
EENPDADREF DDESSEDGEK RDHKVKSRGE DTGASMKHPK HHKNRAHSRS SSEERGLGTK 300
HHSRGSQSRG HEHQDRQSRD QESCHKDRSH REEKSSHRHR EASHKDHYWK KHEQEDKLKG 360
REQEERQDRE GKREKYSSRE QERDRQRNDH DRYSEKEKKR KEKEEHTKAR RERCEDSGKH 420
REREKPEGHG QSSERHRDRR ESSPRSRPKD DLDQERSSKA RNTEKDKGEQ GKPSHSETSL 480
ATKHRLAEER PEKGSEQERP PEAVSKFAKR SNEETVMSAR DRYLARQMAR INAKTYIEKE 540
DD 542 |
Gene Ontology | GO:0016607; C:nuclear speck; ISS:UniProtKB. GO:0030529; C:ribonucleoprotein complex; ISS:UniProtKB. GO:0003729; F:mRNA binding; ISS:UniProtKB. GO:0032502; P:developmental process; ISS:UniProtKB. GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. GO:0006913; P:nucleocytoplasmic transport; ISS:UniProtKB. GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; ISS:UniProtKB. GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |