CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025449
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NAD-dependent protein deacetylase sirtuin-1 
Protein Synonyms/Alias
  
Gene Name
 Sirt1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
697DVNYPSDKS******phosphoglycerylation[1]
Reference
 [1] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
 Moellering RE, Cravatt BF.
 Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 698 AA 
Protein Sequence
MADEVALALQ AAGSPSAAAA MEAASQPADE PLRKRPRRDG PGLGRSPGEP SAAVAPAAAG 60
CEAASAAAPA ALWREAAGAA ASAEREAPAT AVAGDGDNGS GLRREPRAAD DFDDDEGEEE 120
DEAAAAAAAA AIGYRGPYTF VQQHLMIGTD PRTILKDLLP ETIPPPELDD MTLWQIVINI 180
LSEPPKRKKR KDINTIEDAV KLLQECKKII VLTGAGVSVS CGIPDFRSRD GIYARLAVDF 240
PDLPDPQAMF DIEYFRKDPR PFFKFAKEIY PGQFQPSLCH KFIALSDKEG KLLRNYTQNI 300
DTLEQVAGIQ RILQCHGSFA TASCLICKYK VDCEAVRGDI FNQVVPRCPR CPADEPLAIM 360
KPEIVFFGEN LPEQFHRAMK YDKDEVDLLI VIGSSLKVRP VALIPSSIPH EVPQILINRE 420
PLPHLHFDVE LLGDCDVIIN ELCHRLGGEY AKLCCNPVKL SEITEKPPRP QKELVHLSEL 480
PPTPLHISED SSSPERTVPQ DSSVIATLVD QATNNNVNDL EVSESSCVEE KPQEVQTSRN 540
VENINVENPD FKAVGSSTAD KNERTSVAET VRKCWPNRLA KEQISKRLEG NQYLFVPPNR 600
YIFHGAEVYS DSEDDVLSSS SCGSNSDSGT CQSPSLEEPL EDESEIEEFY NGLEDDTERP 660
ECAGGSGFGA DGGDQEVVNE AIATRQELTD VNYPSDKS 698 
Gene Ontology
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0070403; F:NAD+ binding; IEA:InterPro.
 GO:0017136; F:NAD-dependent histone deacetylase activity; IDA:MGI.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0001542; P:ovulation from ovarian follicle; IMP:MGI.
 GO:0007283; P:spermatogenesis; IMP:MGI. 
Interpro
 IPR003000; Sirtuin.
 IPR026591; Sirtuin_cat_small_dom.
 IPR026590; Ssirtuin_cat_dom. 
Pfam
 PF02146; SIR2 
SMART
  
PROSITE
 PS50305; SIRTUIN 
PRINTS