UniProt Accession

 Q59ED7_HUMAN; Q59ED7 

Genbank Protein ID

 AB209874 

Genbank Nucleotide ID

 BAD93111.1 

Protein Name

 NADPH--cytochrome P450 reductase 

Protein Synonyms/Alias

  

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
65	EEVPEFTKIQTLTSS	ubiquitination	[1]
496	TKAGRINKGVATNWL	ubiquitination	[1, 2]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 This enzyme is required for electron transfer from NADP to cytochrome P450 (By similarity). 

Sequence Annotation

  

Keyword

 Endoplasmic reticulum; Membrane; NADP; Oxidoreductase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 686 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0004128; F:cytochrome-b5 reductase activity, acting on NAD(P)H; IEA:Compara.
 GO:0009055; F:electron carrier activity; IEA:Compara.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:Compara.
 GO:0010181; F:FMN binding; IEA:Compara.
 GO:0016787; F:hydrolase activity; IEA:Compara.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0047726; F:iron-cytochrome-c reductase activity; IEA:Compara.
 GO:0050661; F:NADP binding; IEA:Compara.
 GO:0003958; F:NADPH-hemoprotein reductase activity; IEA:EC.
 GO:0009437; P:carnitine metabolic process; IEA:Compara.
 GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEA:Compara.
 GO:0071375; P:cellular response to peptide hormone stimulus; IEA:Compara.
 GO:0070988; P:demethylation; IEA:Compara.
 GO:0019395; P:fatty acid oxidation; IEA:Compara.
 GO:0009812; P:flavonoid metabolic process; IEA:Compara.
 GO:0018393; P:internal peptidyl-lysine acetylation; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0060192; P:negative regulation of lipase activity; IEA:Compara.
 GO:0043602; P:nitrate catabolic process; IEA:Compara.
 GO:0046210; P:nitric oxide catabolic process; IEA:Compara.
 GO:0045542; P:positive regulation of cholesterol biosynthetic process; IEA:Compara.
 GO:0032332; P:positive regulation of chondrocyte differentiation; IEA:Compara.
 GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Compara.
 GO:0090031; P:positive regulation of steroid hormone biosynthetic process; IEA:Compara.
 GO:0003420; P:regulation of growth plate cartilage chondrocyte proliferation; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara. 

Interpro

 IPR003097; FAD-binding_1.
 IPR017927; Fd_Rdtase_FAD-bd.
 IPR001094; Flavdoxin.
 IPR008254; Flavodoxin/NO_synth.
 IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
 IPR023173; NADPH_Cyt_P450_Rdtase_dom3.
 IPR001433; OxRdtase_FAD/NAD-bd.
 IPR023208; P450R.
 IPR017938; Riboflavin_synthase-like_b-brl. 

Pfam

 PF00667; FAD_binding_1
 PF00258; Flavodoxin_1
 PF00175; NAD_binding_1 

SMART

  

PROSITE

 PS51384; FAD_FR
 PS50902; FLAVODOXIN_LIKE 

PRINTS

 PR00369; FLAVODOXIN.
 PR00371; FPNCR.