| Tag | Content |
|---|
| CPLM ID | CPLM-022775 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Multidrug resistance-associated protein 6 |
Protein Synonyms/Alias | ATP-binding cassette sub-family C member 6 |
Gene Name | Abcc6 |
Gene Synonyms/Alias | Mrp6 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 240 | YKKLLGPKDLWSLGR | ubiquitination | [1] | | 273 | CNGLPGHKGHSSVGA | ubiquitination | [1] | | 768 | LARAVYKKAAIYLLD | ubiquitination | [1] | | 1045 | NLLNRFSKETDTVDV | ubiquitination | [1] | | 1289 | LKIHAGEKVGIVGRT | ubiquitination | [1] | | 1300 | VGRTGAGKSSLAWGL | ubiquitination | [1] | | 1485 | PAQLLAQKGLFYRLA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly (By similarity). |
Sequence Annotation | DOMAIN 309 592 ABC transmembrane type-1 1.
DOMAIN 627 851 ABC transporter 1.
DOMAIN 942 1223 ABC transmembrane type-1 2.
DOMAIN 1260 1494 ABC transporter 2.
NP_BIND 661 668 ATP 1 (Potential).
NP_BIND 1294 1301 ATP 2 (Potential).
MOD_RES 250 250 Phosphoserine.
MOD_RES 897 897 Phosphoserine.
CARBOHYD 21 21 N-linked (GlcNAc...) (Potential).
CARBOHYD 341 341 N-linked (GlcNAc...) (Potential). |
Keyword | ATP-binding; Complete proteome; Glycoprotein; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1498 AA |
Protein Sequence | MNRGRSMATP GEQCAGLRVW NQTEQEPAAY HLLSLCFVRA ASSWVPPMYL WVLGPIYLLY 60
IHRHGRCYLR MSHLFKTKMV LGLALILLYT FNVAVPLWRI HQGVPQAPEL LIHPTVWLTT 120
MSFATFLIHM ERRKGVRSSG VLFGYWLLCC ILPGINTVQQ ASAGNFRQEP LHHLATYLCL 180
SLVVAELVLS CLVDQPPFFS EDSQPLNPCP EAEASFPSKA MFWWASGLLW RGYKKLLGPK 240
DLWSLGRENS SEELVSQLER EWRRSCNGLP GHKGHSSVGA PETEAFLQPE RSQRGPLLRA 300
IWRVFRSTFL LGTLSLVISD AFRFAVPKLL SLFLEFMGDR NSSAWTGWLL AVLMFAAACL 360
QTLFEQQHMY RAKVLQMRLR TAITGLVYRK VLVLSSGSRK SSAAGDVVNL VSVDIQRLAE 420
SIIYLNGLWL LFLWIFVCFV YLWQLLGPSA LTAVAVFLSL LPLNFFITKK RGFHQEEQMR 480
QKASRARLTS SMLRTVRTIK SHGWEHAFLE RLLHIRGQEL SALKTSTLLF SVSLVSFQVS 540
TFLVALVVFA VHTLVAEDNA MDAEKAFVTL TVLSILNKAQ AFLPFSVHCI VQARVSFDRL 600
AAFLCLEEVD PNGMIASNSR RSSKDRISVH NGTFAWSQES PPCLHGINLT VPQGCLLAVV 660
GPVGAGKSSL LSALLGELLK VEGSVSIEGS VAYVPQEAWV QNTSVVENVC FRQELDLPWL 720
QKVLDACALG SDVASFPAGV HTPIGEQGMN LSGGQKQRLS LARAVYKKAA IYLLDDPLAA 780
LDAHVSQQVF KQVIGPSGLL QGTTRILVTH TLHVLPQADR ILVLANGTIA EMGSYQDLLQ 840
RNGALVGLLD GARQPAGTHD AATSDDLGGF PGGGRPTCRP DRPRPTEAAP VKGRSTSEVQ 900
MEASLDDPEA TGLTAEEDSV RYGRVKTTIY LSYLRAVGTP LCTYTLFLFL CQQVASFSQG 960
YWLSLWADDP VVDGRQMHAA LRGWVFGLLG CLQAIGLFAS MAAVFLGGAR ASGLLFRSLL 1020
WDVARSPIGF FERTPVGNLL NRFSKETDTV DVDIPDKLRS LLTYAFGLLE VGLAVTMATP 1080
LAIVAILPLM VLYAGFQSLY VATSCQLRRL ESARYSSVCS HMAETFQGSL VVRAFRAQAS 1140
FTAQHDALMD ENQRVSFPKL VADRWLATNL ELLGNGLVFV AATCAVLSKA HLSAGLVGFS 1200
VSAALQVTQT LQWVVRSWTD LENSMVAVER VQDYARIPKE APWRLPTCAA QPLWPCGGQI 1260
EFRDFGLRHR PELPLAVQGV SLKIHAGEKV GIVGRTGAGK SSLAWGLLRL QEAAEGNIWI 1320
DGVPITHVGL HTLRSRITII PQDPVLFPGS LRMNLDLLQE HTDEGIWAAL ETVQLKAFVT 1380
SLPGQLQYEC AGQGDDLSVG QKQLLCLARA LLRKTQILIL DEATASVDPG TEMQMQAALE 1440
RWFTQCTVLL IAHRLRSVMD CARVLVMDEG QVAESGSPAQ LLAQKGLFYR LAHESGLA 1498 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016328; C:lateral plasma membrane; IEA:Compara. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |